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Functional and structural alterations of dorsal attention network in preclinical and early‐stage Alzheimer's disease

OBJECTIVES: Subjective cognitive decline (SCD) and amnestic mild cognitive impairment (aMCI) are known as the preclinical and early stage of Alzheimer's disease (AD). The dorsal attention network (DAN) is mainly responsible for the “top‐down” attention process. However, previous studies mainly...

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Autores principales: Wu, Huimin, Song, Yu, Yang, Xinyi, Chen, Shanshan, Ge, Honglin, Yan, Zheng, Qi, Wenzhang, Yuan, Qianqian, Liang, Xuhong, Lin, Xingjian, Chen, Jiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10173716/
https://www.ncbi.nlm.nih.gov/pubmed/36942514
http://dx.doi.org/10.1111/cns.14092
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author Wu, Huimin
Song, Yu
Yang, Xinyi
Chen, Shanshan
Ge, Honglin
Yan, Zheng
Qi, Wenzhang
Yuan, Qianqian
Liang, Xuhong
Lin, Xingjian
Chen, Jiu
author_facet Wu, Huimin
Song, Yu
Yang, Xinyi
Chen, Shanshan
Ge, Honglin
Yan, Zheng
Qi, Wenzhang
Yuan, Qianqian
Liang, Xuhong
Lin, Xingjian
Chen, Jiu
author_sort Wu, Huimin
collection PubMed
description OBJECTIVES: Subjective cognitive decline (SCD) and amnestic mild cognitive impairment (aMCI) are known as the preclinical and early stage of Alzheimer's disease (AD). The dorsal attention network (DAN) is mainly responsible for the “top‐down” attention process. However, previous studies mainly focused on single functional modality and limited structure. This study aimed to investigate the multimodal alterations of DAN in SCD and aMCI to assess their diagnostic value in preclinical and early‐stage AD. METHODS: Resting‐state functional magnetic resonance imaging (MRI) was carried out to measure the fractional amplitude of low‐frequency fluctuation (fALFF), regional homogeneity (ReHo), and functional connectivity (FC). Structural MRI was used to calculate the gray matter volume (GMV) and cortical thickness. Moreover, receiver‐operating characteristic (ROC) analysis was used to distinguish these alterations in SCD and aMCI. RESULTS: The SCD and aMCI groups showed both decreased ReHo in the right middle temporal gyrus (MTG) and decreased GMV compared to healthy controls (HCs). Especially in the SCD group, there were increased fALFF and increased ReHo in the left inferior occipital gyrus (IOG), decreased fALFF and increased FC in the left inferior parietal lobule (IPL), and reduced cortical thickness in the right inferior temporal gyrus (ITG). Furthermore, functional and structural alterations in the SCD and aMCI groups were closely related to episodic memory (EM), executive function (EF), and information processing speed (IPS). The combination of multiple indicators of DAN had a high accuracy in differentiating clinical stages. CONCLUSIONS: Our current study demonstrated functional and structural alterations of DAN in SCD and aMCI, especially in the MTG, IPL, and SPL. Furthermore, cognitive performance was closely related to these significant alterations. Our study further suggested that the combined multiple indicators of DAN could be acted as the latent neuroimaging markers of preclinical and early‐stage AD for their high diagnostic value.
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spelling pubmed-101737162023-05-12 Functional and structural alterations of dorsal attention network in preclinical and early‐stage Alzheimer's disease Wu, Huimin Song, Yu Yang, Xinyi Chen, Shanshan Ge, Honglin Yan, Zheng Qi, Wenzhang Yuan, Qianqian Liang, Xuhong Lin, Xingjian Chen, Jiu CNS Neurosci Ther Original Articles OBJECTIVES: Subjective cognitive decline (SCD) and amnestic mild cognitive impairment (aMCI) are known as the preclinical and early stage of Alzheimer's disease (AD). The dorsal attention network (DAN) is mainly responsible for the “top‐down” attention process. However, previous studies mainly focused on single functional modality and limited structure. This study aimed to investigate the multimodal alterations of DAN in SCD and aMCI to assess their diagnostic value in preclinical and early‐stage AD. METHODS: Resting‐state functional magnetic resonance imaging (MRI) was carried out to measure the fractional amplitude of low‐frequency fluctuation (fALFF), regional homogeneity (ReHo), and functional connectivity (FC). Structural MRI was used to calculate the gray matter volume (GMV) and cortical thickness. Moreover, receiver‐operating characteristic (ROC) analysis was used to distinguish these alterations in SCD and aMCI. RESULTS: The SCD and aMCI groups showed both decreased ReHo in the right middle temporal gyrus (MTG) and decreased GMV compared to healthy controls (HCs). Especially in the SCD group, there were increased fALFF and increased ReHo in the left inferior occipital gyrus (IOG), decreased fALFF and increased FC in the left inferior parietal lobule (IPL), and reduced cortical thickness in the right inferior temporal gyrus (ITG). Furthermore, functional and structural alterations in the SCD and aMCI groups were closely related to episodic memory (EM), executive function (EF), and information processing speed (IPS). The combination of multiple indicators of DAN had a high accuracy in differentiating clinical stages. CONCLUSIONS: Our current study demonstrated functional and structural alterations of DAN in SCD and aMCI, especially in the MTG, IPL, and SPL. Furthermore, cognitive performance was closely related to these significant alterations. Our study further suggested that the combined multiple indicators of DAN could be acted as the latent neuroimaging markers of preclinical and early‐stage AD for their high diagnostic value. John Wiley and Sons Inc. 2023-03-21 /pmc/articles/PMC10173716/ /pubmed/36942514 http://dx.doi.org/10.1111/cns.14092 Text en © 2023 The Authors. CNS Neuroscience & Therapeutics published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Wu, Huimin
Song, Yu
Yang, Xinyi
Chen, Shanshan
Ge, Honglin
Yan, Zheng
Qi, Wenzhang
Yuan, Qianqian
Liang, Xuhong
Lin, Xingjian
Chen, Jiu
Functional and structural alterations of dorsal attention network in preclinical and early‐stage Alzheimer's disease
title Functional and structural alterations of dorsal attention network in preclinical and early‐stage Alzheimer's disease
title_full Functional and structural alterations of dorsal attention network in preclinical and early‐stage Alzheimer's disease
title_fullStr Functional and structural alterations of dorsal attention network in preclinical and early‐stage Alzheimer's disease
title_full_unstemmed Functional and structural alterations of dorsal attention network in preclinical and early‐stage Alzheimer's disease
title_short Functional and structural alterations of dorsal attention network in preclinical and early‐stage Alzheimer's disease
title_sort functional and structural alterations of dorsal attention network in preclinical and early‐stage alzheimer's disease
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10173716/
https://www.ncbi.nlm.nih.gov/pubmed/36942514
http://dx.doi.org/10.1111/cns.14092
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