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FGF/FGFR system in the central nervous system demyelinating disease: Recent progress and implications for multiple sclerosis

BACKGROUND: With millions of victims worldwide, multiple sclerosis is the second most common cause of disability among young adults. Although formidable advancements have been made in understanding the disease, the neurodegeneration associated with multiple sclerosis is only partially counteracted b...

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Autores principales: Zhang, Qingxiang, Chen, Zhiguo, Zhang, Kaili, Zhu, Jie, Jin, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10173727/
https://www.ncbi.nlm.nih.gov/pubmed/36924298
http://dx.doi.org/10.1111/cns.14176
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author Zhang, Qingxiang
Chen, Zhiguo
Zhang, Kaili
Zhu, Jie
Jin, Tao
author_facet Zhang, Qingxiang
Chen, Zhiguo
Zhang, Kaili
Zhu, Jie
Jin, Tao
author_sort Zhang, Qingxiang
collection PubMed
description BACKGROUND: With millions of victims worldwide, multiple sclerosis is the second most common cause of disability among young adults. Although formidable advancements have been made in understanding the disease, the neurodegeneration associated with multiple sclerosis is only partially counteracted by current treatments, and effective therapy for progressive multiple sclerosis remains an unmet need. Therefore, new approaches are required to delay demyelination and the resulting disability and to restore neural function by promoting remyelination and neuronal repair. AIMS: The article reviews the latest literature in this field. MATERIALS AND METHODS: The fibroblast growth factor (FGF) signaling pathway is a promising target in progressive multiple sclerosis. DISCUSSION: FGF signal transduction contributes to establishing the oligodendrocyte lineage, neural stem cell proliferation and differentiation, and myelination of the central nervous system. Furthermore, FGF signaling is implicated in the control of neuroinflammation. In recent years, interventions targeting FGF, and its receptor (FGFR) have been shown to ameliorate autoimmune encephalomyelitis symptoms in multiple sclerosis animal models moderately. CONCLUSION: Here, we summarize the recent findings and investigate the role of FGF/FGFR signaling in the onset and progression, discuss the potential therapeutic advances, and offer fresh insights into managing multiple sclerosis.
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spelling pubmed-101737272023-05-12 FGF/FGFR system in the central nervous system demyelinating disease: Recent progress and implications for multiple sclerosis Zhang, Qingxiang Chen, Zhiguo Zhang, Kaili Zhu, Jie Jin, Tao CNS Neurosci Ther Reviews BACKGROUND: With millions of victims worldwide, multiple sclerosis is the second most common cause of disability among young adults. Although formidable advancements have been made in understanding the disease, the neurodegeneration associated with multiple sclerosis is only partially counteracted by current treatments, and effective therapy for progressive multiple sclerosis remains an unmet need. Therefore, new approaches are required to delay demyelination and the resulting disability and to restore neural function by promoting remyelination and neuronal repair. AIMS: The article reviews the latest literature in this field. MATERIALS AND METHODS: The fibroblast growth factor (FGF) signaling pathway is a promising target in progressive multiple sclerosis. DISCUSSION: FGF signal transduction contributes to establishing the oligodendrocyte lineage, neural stem cell proliferation and differentiation, and myelination of the central nervous system. Furthermore, FGF signaling is implicated in the control of neuroinflammation. In recent years, interventions targeting FGF, and its receptor (FGFR) have been shown to ameliorate autoimmune encephalomyelitis symptoms in multiple sclerosis animal models moderately. CONCLUSION: Here, we summarize the recent findings and investigate the role of FGF/FGFR signaling in the onset and progression, discuss the potential therapeutic advances, and offer fresh insights into managing multiple sclerosis. John Wiley and Sons Inc. 2023-03-16 /pmc/articles/PMC10173727/ /pubmed/36924298 http://dx.doi.org/10.1111/cns.14176 Text en © 2023 The Authors. CNS Neuroscience & Therapeutics published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Zhang, Qingxiang
Chen, Zhiguo
Zhang, Kaili
Zhu, Jie
Jin, Tao
FGF/FGFR system in the central nervous system demyelinating disease: Recent progress and implications for multiple sclerosis
title FGF/FGFR system in the central nervous system demyelinating disease: Recent progress and implications for multiple sclerosis
title_full FGF/FGFR system in the central nervous system demyelinating disease: Recent progress and implications for multiple sclerosis
title_fullStr FGF/FGFR system in the central nervous system demyelinating disease: Recent progress and implications for multiple sclerosis
title_full_unstemmed FGF/FGFR system in the central nervous system demyelinating disease: Recent progress and implications for multiple sclerosis
title_short FGF/FGFR system in the central nervous system demyelinating disease: Recent progress and implications for multiple sclerosis
title_sort fgf/fgfr system in the central nervous system demyelinating disease: recent progress and implications for multiple sclerosis
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10173727/
https://www.ncbi.nlm.nih.gov/pubmed/36924298
http://dx.doi.org/10.1111/cns.14176
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