Nutrient-sensing AgRP neurons relay control of liver autophagy during energy deprivation

Autophagy represents a key regulator of aging and metabolism in sensing energy deprivation. We find that fasting in mice activates autophagy in the liver paralleled by activation of hypothalamic AgRP neurons. Optogenetic and chemogenetic activation of AgRP neurons induces autophagy, alters phosphory...

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Detalles Bibliográficos
Autores principales: Chen, Weiyi, Mehlkop, Oliver, Scharn, Alexandra, Nolte, Hendrik, Klemm, Paul, Henschke, Sinika, Steuernagel, Lukas, Sotelo-Hitschfeld, Tamara, Kaya, Ecem, Wunderlich, Claudia Maria, Langer, Thomas, Kononenko, Natalia L., Giavalisco, Patrick, Brüning, Jens Claus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10173804/
https://www.ncbi.nlm.nih.gov/pubmed/37075752
http://dx.doi.org/10.1016/j.cmet.2023.03.019

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