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Current status and prospects of basic research and clinical application of mesenchymal stem cells in acute respiratory distress syndrome

Acute respiratory distress syndrome (ARDS) is a common and clinically devastating disease that causes respiratory failure. Morbidity and mortality of patients in intensive care units are stubbornly high, and various complications severely affect the quality of life of survivors. The pathophysiology...

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Autores principales: Liang, Tian-Yu, Lu, Li-Hai, Tang, Si-Yu, Zheng, Zi-Hao, Shi, Kai, Liu, Jing-Quan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10173811/
https://www.ncbi.nlm.nih.gov/pubmed/37180997
http://dx.doi.org/10.4252/wjsc.v15.i4.150
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author Liang, Tian-Yu
Lu, Li-Hai
Tang, Si-Yu
Zheng, Zi-Hao
Shi, Kai
Liu, Jing-Quan
author_facet Liang, Tian-Yu
Lu, Li-Hai
Tang, Si-Yu
Zheng, Zi-Hao
Shi, Kai
Liu, Jing-Quan
author_sort Liang, Tian-Yu
collection PubMed
description Acute respiratory distress syndrome (ARDS) is a common and clinically devastating disease that causes respiratory failure. Morbidity and mortality of patients in intensive care units are stubbornly high, and various complications severely affect the quality of life of survivors. The pathophysiology of ARDS includes increased alveolar–capillary membrane permeability, an influx of protein-rich pulmonary edema fluid, and surfactant dysfunction leading to severe hypoxemia. At present, the main treatment for ARDS is mechanical treatment combined with diuretics to reduce pulmonary edema, which primarily improves symptoms, but the prognosis of patients with ARDS is still very poor. Mesenchymal stem cells (MSCs) are stromal cells that possess the capacity to self-renew and also exhibit multilineage differentiation. MSCs can be isolated from a variety of tissues, such as the umbilical cord, endometrial polyps, menstrual blood, bone marrow, and adipose tissues. Studies have confirmed the critical healing and immunomodulatory properties of MSCs in the treatment of a variety of diseases. Recently, the potential of stem cells in treating ARDS has been explored via basic research and clinical trials. The efficacy of MSCs has been shown in a variety of in vivo models of ARDS, reducing bacterial pneumonia and ischemia-reperfusion injury while promoting the repair of ventilator-induced lung injury. This article reviews the current basic research findings and clinical applications of MSCs in the treatment of ARDS in order to emphasize the clinical prospects of MSCs.
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spelling pubmed-101738112023-05-12 Current status and prospects of basic research and clinical application of mesenchymal stem cells in acute respiratory distress syndrome Liang, Tian-Yu Lu, Li-Hai Tang, Si-Yu Zheng, Zi-Hao Shi, Kai Liu, Jing-Quan World J Stem Cells Review Acute respiratory distress syndrome (ARDS) is a common and clinically devastating disease that causes respiratory failure. Morbidity and mortality of patients in intensive care units are stubbornly high, and various complications severely affect the quality of life of survivors. The pathophysiology of ARDS includes increased alveolar–capillary membrane permeability, an influx of protein-rich pulmonary edema fluid, and surfactant dysfunction leading to severe hypoxemia. At present, the main treatment for ARDS is mechanical treatment combined with diuretics to reduce pulmonary edema, which primarily improves symptoms, but the prognosis of patients with ARDS is still very poor. Mesenchymal stem cells (MSCs) are stromal cells that possess the capacity to self-renew and also exhibit multilineage differentiation. MSCs can be isolated from a variety of tissues, such as the umbilical cord, endometrial polyps, menstrual blood, bone marrow, and adipose tissues. Studies have confirmed the critical healing and immunomodulatory properties of MSCs in the treatment of a variety of diseases. Recently, the potential of stem cells in treating ARDS has been explored via basic research and clinical trials. The efficacy of MSCs has been shown in a variety of in vivo models of ARDS, reducing bacterial pneumonia and ischemia-reperfusion injury while promoting the repair of ventilator-induced lung injury. This article reviews the current basic research findings and clinical applications of MSCs in the treatment of ARDS in order to emphasize the clinical prospects of MSCs. Baishideng Publishing Group Inc 2023-04-26 2023-04-26 /pmc/articles/PMC10173811/ /pubmed/37180997 http://dx.doi.org/10.4252/wjsc.v15.i4.150 Text en ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Review
Liang, Tian-Yu
Lu, Li-Hai
Tang, Si-Yu
Zheng, Zi-Hao
Shi, Kai
Liu, Jing-Quan
Current status and prospects of basic research and clinical application of mesenchymal stem cells in acute respiratory distress syndrome
title Current status and prospects of basic research and clinical application of mesenchymal stem cells in acute respiratory distress syndrome
title_full Current status and prospects of basic research and clinical application of mesenchymal stem cells in acute respiratory distress syndrome
title_fullStr Current status and prospects of basic research and clinical application of mesenchymal stem cells in acute respiratory distress syndrome
title_full_unstemmed Current status and prospects of basic research and clinical application of mesenchymal stem cells in acute respiratory distress syndrome
title_short Current status and prospects of basic research and clinical application of mesenchymal stem cells in acute respiratory distress syndrome
title_sort current status and prospects of basic research and clinical application of mesenchymal stem cells in acute respiratory distress syndrome
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10173811/
https://www.ncbi.nlm.nih.gov/pubmed/37180997
http://dx.doi.org/10.4252/wjsc.v15.i4.150
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