Treatment of status epilepticus: Physiology, pharmacology, and future directions

The review presents retrospective, present views and future perspectives on the treatment of status epilepticus (SE). First, presynaptic, postsynaptic, and extrasynaptic mechanisms underlying sustaining ongoing seizure activity are highlighted. Next, mechanism‐based choices of antiseizure medication...

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Detalles Bibliográficos
Autor principal: Sankar, Raman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Invited Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10173851/
https://www.ncbi.nlm.nih.gov/pubmed/36929735
http://dx.doi.org/10.1002/epi4.12725
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author Sankar, Raman
author_facet Sankar, Raman
author_sort Sankar, Raman
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description The review presents retrospective, present views and future perspectives on the treatment of status epilepticus (SE). First, presynaptic, postsynaptic, and extrasynaptic mechanisms underlying sustaining ongoing seizure activity are highlighted. Next, mechanism‐based choices of antiseizure medications capable of promptly arresting SE are introduced. Finally, challenges associated with translating the advances in laboratory research in clinical practice are discussed.
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spelling pubmed-101738512023-05-12 Treatment of status epilepticus: Physiology, pharmacology, and future directions Sankar, Raman Epilepsia Open Invited Article The review presents retrospective, present views and future perspectives on the treatment of status epilepticus (SE). First, presynaptic, postsynaptic, and extrasynaptic mechanisms underlying sustaining ongoing seizure activity are highlighted. Next, mechanism‐based choices of antiseizure medications capable of promptly arresting SE are introduced. Finally, challenges associated with translating the advances in laboratory research in clinical practice are discussed. John Wiley and Sons Inc. 2023-04-20 /pmc/articles/PMC10173851/ /pubmed/36929735 http://dx.doi.org/10.1002/epi4.12725 Text en © 2023 The Author. Epilepsia Open published by Wiley Periodicals LLC on behalf of International League Against Epilepsy. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Invited Article
Sankar, Raman
Treatment of status epilepticus: Physiology, pharmacology, and future directions
title Treatment of status epilepticus: Physiology, pharmacology, and future directions
title_full Treatment of status epilepticus: Physiology, pharmacology, and future directions
title_fullStr Treatment of status epilepticus: Physiology, pharmacology, and future directions
title_full_unstemmed Treatment of status epilepticus: Physiology, pharmacology, and future directions
title_short Treatment of status epilepticus: Physiology, pharmacology, and future directions
title_sort treatment of status epilepticus: physiology, pharmacology, and future directions
topic Invited Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10173851/
https://www.ncbi.nlm.nih.gov/pubmed/36929735
http://dx.doi.org/10.1002/epi4.12725
work_keys_str_mv AT sankarraman treatmentofstatusepilepticusphysiologypharmacologyandfuturedirections

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