TB granuloma: CD30 co-stimulation for CD4(+) T cell co-operation

Tuberculosis granuloma T cells express an array of mediators including the CD30 co-stimulatory receptor and its ligand, CD153. CD4 T effector cells require signals through CD30, potentially provided co-operatively by other T cells, to completely differentiate and protect against disease (Foreman et...

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Detalles Bibliográficos
Autores principales: Gress, Abigail R., Bold, Tyler D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2023
Materias:
Insights
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10174186/
https://www.ncbi.nlm.nih.gov/pubmed/37158981
http://dx.doi.org/10.1084/jem.20230547
Descripción
Sumario:Tuberculosis granuloma T cells express an array of mediators including the CD30 co-stimulatory receptor and its ligand, CD153. CD4 T effector cells require signals through CD30, potentially provided co-operatively by other T cells, to completely differentiate and protect against disease (Foreman et al., 2023. J. Exp. Med. https://doi.org/10.1084/jem.20222090).

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