A two-step mitochondrial import pathway couples the disulfide relay with matrix complex I biogenesis

Mitochondria critically rely on protein import and its tight regulation. Here, we found that the complex I assembly factor NDUFAF8 follows a two-step import pathway linking IMS and matrix import systems. A weak targeting sequence drives TIM23-dependent NDUFAF8 matrix import, and en route, allows exp...

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Detalles Bibliográficos
Autores principales: Peker, Esra, Weiss, Konstantin, Song, Jiyao, Zarges, Christine, Gerlich, Sarah, Boehm, Volker, Trifunovic, Aleksandra, Langer, Thomas, Gehring, Niels H., Becker, Thomas, Riemer, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2023
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10174193/
https://www.ncbi.nlm.nih.gov/pubmed/37159021
http://dx.doi.org/10.1083/jcb.202210019

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