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Demethylating therapy increases cytotoxicity of CD44v6 CAR-T cells against acute myeloid leukemia

BACKGROUND: CD44v6 chimeric antigen receptor T (CD44v6 CAR-T) cells demonstrate strong anti-tumor ability and safety in acute myeloid leukemia (AML). However, the expression of CD44v6 on T cells leads to transient fratricide and exhaustion of CD44v6 CAR-T cells, which affect the application of CD44v...

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Detalles Bibliográficos
Autores principales:	Tang, Ling, Kong, Yingjie, Wang, Haobing, Zou, Ping, Sun, Ting, Liu, Ying, Zhang, Juan, Jin, Na, Mao, Hanwen, Zhu, Xiaojian, Wang, Jue, Meng, Fankai, You, Yong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10174291/ https://www.ncbi.nlm.nih.gov/pubmed/37180104 http://dx.doi.org/10.3389/fimmu.2023.1145441

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