Activation of the integrated stress response (ISR) pathways in response to Ref-1 inhibition in human pancreatic cancer and its tumor microenvironment

Pancreatic cancer or pancreatic ductal adenocarcinoma (PDAC) is characterized by a profound inflammatory tumor microenvironment (TME) with high heterogeneity, metastatic propensity, and extreme hypoxia. The integrated stress response (ISR) pathway features a family of protein kinases that phosphoryl...

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Detalles Bibliográficos
Autores principales: Mijit, Mahmut, Boner, Megan, Cordova, Ricardo A., Gampala, Silpa, Kpenu, Eyram, Klunk, Angela J., Zhang, Chi, Kelley, MarK R., Staschke, Kirk A., Fishel, Melissa L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10174294/
https://www.ncbi.nlm.nih.gov/pubmed/37181357
http://dx.doi.org/10.3389/fmed.2023.1146115

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