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Substrate-specific effects of natural genetic variation on proteasome activity

Protein degradation is an essential biological process that regulates protein abundance and removes misfolded and damaged proteins from cells. In eukaryotes, most protein degradation occurs through the stepwise actions of two functionally distinct entities, the ubiquitin system and the proteasome. U...

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Detalles Bibliográficos
Autores principales: Collins, Mahlon A., Avery, Randi, Albert, Frank W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10174532/
https://www.ncbi.nlm.nih.gov/pubmed/37126494
http://dx.doi.org/10.1371/journal.pgen.1010734