The calcium channel Orai1 is required for osteoblast development: Studies in a chimeric mouse with variable in vivo Runx-cre deletion of Orai-1

The calcium-selective ion channel Orai1 has a complex role in bone homeostasis, with defects in both bone production and resorption detected in Orai1 germline knock-out mice. To determine whether Orai1 has a direct, cell-intrinsic role in osteoblast differentiation and function, we bred Orai1 flox/f...

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Detalles Bibliográficos
Autores principales: Robinson, Lisa J., Soboloff, Jonathan, Tourkova, Irina L., Larrouture, Quitterie C., Onwuka, Kelechi M., Papachristou, Dionysios J., Gross, Scott, Hooper, Robert, Samakai, Elsie, Worley, Paul F., Liu, Peng, Tuckermann, Jan, Witt, Michelle R., Blair, Harry C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10174572/
https://www.ncbi.nlm.nih.gov/pubmed/37167218
http://dx.doi.org/10.1371/journal.pone.0264596

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