Monoterpenoid aryl hydrocarbon receptor allosteric antagonists protect against ultraviolet skin damage in female mice

The human aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that is a pivotal regulator of human physiology and pathophysiology. Allosteric inhibition of AhR was previously thought to be untenable. Here, we identify carvones as noncompetitive, insurmountable antagonists of A...

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Detalles Bibliográficos
Autores principales: Ondrová, Karolína, Zůvalová, Iveta, Vyhlídalová, Barbora, Krasulová, Kristýna, Miková, Eva, Vrzal, Radim, Nádvorník, Petr, Nepal, Binod, Kortagere, Sandhya, Kopečná, Martina, Kopečný, David, Šebela, Marek, Rastinejad, Fraydoon, Pu, Hua, Soural, Miroslav, Rolfes, Katharina Maria, Haarmann-Stemmann, Thomas, Li, Hao, Mani, Sridhar, Dvořák, Zdeněk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10174618/
https://www.ncbi.nlm.nih.gov/pubmed/37169746
http://dx.doi.org/10.1038/s41467-023-38478-6

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