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Single-cell transcriptomics of a dynamic cell behavior in murine airways
Despite advances in high-dimensional cellular analysis, the molecular profiling of dynamic behaviors of cells in their native environment remains a major challenge. We present a method that allows us to couple the physiological behaviors of cells in an intact murine tissue to deep molecular profilin...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10174686/ https://www.ncbi.nlm.nih.gov/pubmed/37083555 http://dx.doi.org/10.7554/eLife.76645 |
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author | Kwok, Sheldon JJ Montoro, Daniel T Haber, Adam L Yun, Seok-Hyun Vinarsky, Vladimir |
author_facet | Kwok, Sheldon JJ Montoro, Daniel T Haber, Adam L Yun, Seok-Hyun Vinarsky, Vladimir |
author_sort | Kwok, Sheldon JJ |
collection | PubMed |
description | Despite advances in high-dimensional cellular analysis, the molecular profiling of dynamic behaviors of cells in their native environment remains a major challenge. We present a method that allows us to couple the physiological behaviors of cells in an intact murine tissue to deep molecular profiling of individual cells. This method enabled us to establish a novel molecular signature for a striking migratory cellular behavior following injury in murine airways. |
format | Online Article Text |
id | pubmed-10174686 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-101746862023-05-12 Single-cell transcriptomics of a dynamic cell behavior in murine airways Kwok, Sheldon JJ Montoro, Daniel T Haber, Adam L Yun, Seok-Hyun Vinarsky, Vladimir eLife Developmental Biology Despite advances in high-dimensional cellular analysis, the molecular profiling of dynamic behaviors of cells in their native environment remains a major challenge. We present a method that allows us to couple the physiological behaviors of cells in an intact murine tissue to deep molecular profiling of individual cells. This method enabled us to establish a novel molecular signature for a striking migratory cellular behavior following injury in murine airways. eLife Sciences Publications, Ltd 2023-04-21 /pmc/articles/PMC10174686/ /pubmed/37083555 http://dx.doi.org/10.7554/eLife.76645 Text en © 2023, Kwok, Montoro, Haber et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Developmental Biology Kwok, Sheldon JJ Montoro, Daniel T Haber, Adam L Yun, Seok-Hyun Vinarsky, Vladimir Single-cell transcriptomics of a dynamic cell behavior in murine airways |
title | Single-cell transcriptomics of a dynamic cell behavior in murine airways |
title_full | Single-cell transcriptomics of a dynamic cell behavior in murine airways |
title_fullStr | Single-cell transcriptomics of a dynamic cell behavior in murine airways |
title_full_unstemmed | Single-cell transcriptomics of a dynamic cell behavior in murine airways |
title_short | Single-cell transcriptomics of a dynamic cell behavior in murine airways |
title_sort | single-cell transcriptomics of a dynamic cell behavior in murine airways |
topic | Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10174686/ https://www.ncbi.nlm.nih.gov/pubmed/37083555 http://dx.doi.org/10.7554/eLife.76645 |
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