RNA Polymerase II transcription independent of TBP in murine embryonic stem cells

Transcription by RNA Polymerase II (Pol II) is initiated by the hierarchical assembly of the pre-initiation complex onto promoter DNA. Decades of research have shown that the TATA-box binding protein (TBP) is essential for Pol II loading and initiation. Here, we report instead that acute depletion o...

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Detalles Bibliográficos
Autores principales: Kwan, James ZJ, Nguyen, Thomas F, Uzozie, Anuli C, Budzynski, Marek A, Cui, Jieying, Lee, Joseph MC, Van Petegem, Filip, Lange, Philipp F, Teves, Sheila S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10174690/
https://www.ncbi.nlm.nih.gov/pubmed/36995326
http://dx.doi.org/10.7554/eLife.83810

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