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High-grade serous ovarian carcinoma organoids as models of chromosomal instability

High-grade serous ovarian carcinoma (HGSOC) is the most genomically complex cancer, characterized by ubiquitous TP53 mutation, profound chromosomal instability, and heterogeneity. The mutational processes driving chromosomal instability in HGSOC can be distinguished by specific copy number signature...

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Detalles Bibliográficos
Autores principales:	Vias, Maria, Morrill Gavarró, Lena, Sauer, Carolin M, Sanders, Deborah A, Piskorz, Anna M, Couturier, Dominique-Laurent, Ballereau, Stéphane, Hernando, Bárbara, Schneider, Michael P, Hall, James, Correia-Martins, Filipe, Markowetz, Florian, Macintyre, Geoff, Brenton, James D
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2023
Materias:	Cancer Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10174694/ https://www.ncbi.nlm.nih.gov/pubmed/37166279 http://dx.doi.org/10.7554/eLife.83867

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