The efficacy and safety of apatinib in patients with heavily pretreated end-stage cancer: a retrospective study

BACKGROUND: Anti-angiogenesis therapy has been a vital treatment option in a variety of cancers. Assessing the efficacy and safety of apatinib in patients with heavily pretreated end-stage cancer is essential. METHODS: Thirty patients with end-stage cancer who were heavily pretreated were enrolled i...

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Detalles Bibliográficos
Autores principales: Li, Zhenyu, Zhou, Xiaoshu, Wang, Shuai, Shi, Liangliang, Meng, Rui, Dai, Xiaofang, Liu, Yi, Lin, Xueke, Xiao, Yong, Peng, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10174995/
https://www.ncbi.nlm.nih.gov/pubmed/37180651
http://dx.doi.org/10.21037/tcr-22-2080
Descripción
Sumario:BACKGROUND: Anti-angiogenesis therapy has been a vital treatment option in a variety of cancers. Assessing the efficacy and safety of apatinib in patients with heavily pretreated end-stage cancer is essential. METHODS: Thirty patients with end-stage cancer who were heavily pretreated were enrolled in this study. All patients received oral administration of apatinib (125–500 mg/d) between May 2015 and November 2016. Dose reduction or elevation was conducted based on adverse events and doctors’ judgments. RESULTS: Prior to the apatinib treatment, the enrolled patients received a median of 1.2 surgeries (range, 0–7), 1.6 sessions of radiotherapies (range, 0–6), and 10.2 cycles of chemotherapy (range, 0–60); 43.3% of patients had uncontrolled local lesions, 83.3% of patients had uncontrolled multiple metastases, and 30.0% of patients had both. After the treatment, 25 patients had valuable data, 6 (24.0%) patients achieved partial response (PR), and 12 (48.0%) patients had stable disease (SD). The disease control rate (DCR) was 72.0%. The PR and SD rates were 20.0% and 40.0%, respectively, and the DCR was 60.0% in the intent-to-treat (ITT) analysis. Meanwhile, the median progression-free survival (PFS) was 2.6 (range, 0.7–5.4) months, and the median overall survival (OS) was 3.8 (range, 1.0–12.0) months. Furthermore, the PR rate and DCR in patients with squamous cell cancer (SCC) were 45.5% and 81.8%, respectively; those in patients with adenocarcinoma (ADC) were 8.3% and 58.3%, respectively. The adverse events were generally mild. The most common adverse events were hyperbilirubinemia (53.3%), elevated transaminase (36.7%), anemia (30.0%), thrombocytopenia (30.0%), hematuria (30.0%), fatigue (26.7%), and leukopenia (20.0%). CONCLUSIONS: The results of this study demonstrate the efficacy and safety of apatinib and support the further development of apatinib as a potential treatment option for patients with heavily pretreated end-stage cancer.

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