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The Role of Macrophage Autophagy in Asthma: A Novel Therapeutic Strategy

Asthma is a chronic respiratory disease frequently associated with airway inflammation and remodeling. The development of asthma involves various inflammatory phenotypes that impact therapeutic effects, and macrophages are master innate immune cells in the airway that exert diverse functions includi...

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Detalles Bibliográficos
Autores principales: Wang, Lijie, Yuan, Xingxing, Li, Zhuying, Zhi, Fumin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10175021/
https://www.ncbi.nlm.nih.gov/pubmed/37181813
http://dx.doi.org/10.1155/2023/7529685
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author Wang, Lijie
Yuan, Xingxing
Li, Zhuying
Zhi, Fumin
author_facet Wang, Lijie
Yuan, Xingxing
Li, Zhuying
Zhi, Fumin
author_sort Wang, Lijie
collection PubMed
description Asthma is a chronic respiratory disease frequently associated with airway inflammation and remodeling. The development of asthma involves various inflammatory phenotypes that impact therapeutic effects, and macrophages are master innate immune cells in the airway that exert diverse functions including phagocytosis, antigen presentation, and pathogen clearance, playing an important role in the pathogeneses of asthma. Recent studies have indicated that autophagy of macrophages affects polarization of phenotype and regulation of inflammation, which implies that regulating autophagy of macrophages may be a potential strategy for the treatment of asthma. Thus, this review summarizes the signaling pathways and effects of macrophage autophagy in asthma, which will provide a tactic for the development of novel targets for the treatment of this disease.
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spelling pubmed-101750212023-05-12 The Role of Macrophage Autophagy in Asthma: A Novel Therapeutic Strategy Wang, Lijie Yuan, Xingxing Li, Zhuying Zhi, Fumin Mediators Inflamm Review Article Asthma is a chronic respiratory disease frequently associated with airway inflammation and remodeling. The development of asthma involves various inflammatory phenotypes that impact therapeutic effects, and macrophages are master innate immune cells in the airway that exert diverse functions including phagocytosis, antigen presentation, and pathogen clearance, playing an important role in the pathogeneses of asthma. Recent studies have indicated that autophagy of macrophages affects polarization of phenotype and regulation of inflammation, which implies that regulating autophagy of macrophages may be a potential strategy for the treatment of asthma. Thus, this review summarizes the signaling pathways and effects of macrophage autophagy in asthma, which will provide a tactic for the development of novel targets for the treatment of this disease. Hindawi 2023-05-04 /pmc/articles/PMC10175021/ /pubmed/37181813 http://dx.doi.org/10.1155/2023/7529685 Text en Copyright © 2023 Lijie Wang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Wang, Lijie
Yuan, Xingxing
Li, Zhuying
Zhi, Fumin
The Role of Macrophage Autophagy in Asthma: A Novel Therapeutic Strategy
title The Role of Macrophage Autophagy in Asthma: A Novel Therapeutic Strategy
title_full The Role of Macrophage Autophagy in Asthma: A Novel Therapeutic Strategy
title_fullStr The Role of Macrophage Autophagy in Asthma: A Novel Therapeutic Strategy
title_full_unstemmed The Role of Macrophage Autophagy in Asthma: A Novel Therapeutic Strategy
title_short The Role of Macrophage Autophagy in Asthma: A Novel Therapeutic Strategy
title_sort role of macrophage autophagy in asthma: a novel therapeutic strategy
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10175021/
https://www.ncbi.nlm.nih.gov/pubmed/37181813
http://dx.doi.org/10.1155/2023/7529685
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