Cargando…

Effects of Ferroptosis on Cardiovascular Diseases

Ferroptosis is a novel form of programmed cell death characterized by the accumulation of iron-dependent lipid peroxides, which causes membrane injury. Under the catalysis of iron ions, cells deficient in glutathione peroxidase (GPX4) cannot preserve the balance in lipid oxidative metabolism, and th...

Descripción completa

Detalles Bibliográficos
Autores principales: Xu, Jiayi, Pi, Jinkui, Zhang, Yanjing, Zhou, Jinhan, Zhang, Shuxia, Wu, Sisi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10175025/
https://www.ncbi.nlm.nih.gov/pubmed/37181809
http://dx.doi.org/10.1155/2023/6653202
_version_ 1785040160125091840
author Xu, Jiayi
Pi, Jinkui
Zhang, Yanjing
Zhou, Jinhan
Zhang, Shuxia
Wu, Sisi
author_facet Xu, Jiayi
Pi, Jinkui
Zhang, Yanjing
Zhou, Jinhan
Zhang, Shuxia
Wu, Sisi
author_sort Xu, Jiayi
collection PubMed
description Ferroptosis is a novel form of programmed cell death characterized by the accumulation of iron-dependent lipid peroxides, which causes membrane injury. Under the catalysis of iron ions, cells deficient in glutathione peroxidase (GPX4) cannot preserve the balance in lipid oxidative metabolism, and the buildup of reactive oxygen species on the membrane lipids leads to cell death. An increasing body of evidence suggests that ferroptosis plays a significant role in the development and occurrence of cardiovascular diseases. In this paper, we mainly elaborated on the molecular mechanisms regulating ferroptosis and its impact on cardiovascular disease to lay the groundwork for future studies on the prophylaxis and treatment of this patient population.
format Online
Article
Text
id pubmed-10175025
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-101750252023-05-12 Effects of Ferroptosis on Cardiovascular Diseases Xu, Jiayi Pi, Jinkui Zhang, Yanjing Zhou, Jinhan Zhang, Shuxia Wu, Sisi Mediators Inflamm Review Article Ferroptosis is a novel form of programmed cell death characterized by the accumulation of iron-dependent lipid peroxides, which causes membrane injury. Under the catalysis of iron ions, cells deficient in glutathione peroxidase (GPX4) cannot preserve the balance in lipid oxidative metabolism, and the buildup of reactive oxygen species on the membrane lipids leads to cell death. An increasing body of evidence suggests that ferroptosis plays a significant role in the development and occurrence of cardiovascular diseases. In this paper, we mainly elaborated on the molecular mechanisms regulating ferroptosis and its impact on cardiovascular disease to lay the groundwork for future studies on the prophylaxis and treatment of this patient population. Hindawi 2023-05-04 /pmc/articles/PMC10175025/ /pubmed/37181809 http://dx.doi.org/10.1155/2023/6653202 Text en Copyright © 2023 Jiayi Xu et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Xu, Jiayi
Pi, Jinkui
Zhang, Yanjing
Zhou, Jinhan
Zhang, Shuxia
Wu, Sisi
Effects of Ferroptosis on Cardiovascular Diseases
title Effects of Ferroptosis on Cardiovascular Diseases
title_full Effects of Ferroptosis on Cardiovascular Diseases
title_fullStr Effects of Ferroptosis on Cardiovascular Diseases
title_full_unstemmed Effects of Ferroptosis on Cardiovascular Diseases
title_short Effects of Ferroptosis on Cardiovascular Diseases
title_sort effects of ferroptosis on cardiovascular diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10175025/
https://www.ncbi.nlm.nih.gov/pubmed/37181809
http://dx.doi.org/10.1155/2023/6653202
work_keys_str_mv AT xujiayi effectsofferroptosisoncardiovasculardiseases
AT pijinkui effectsofferroptosisoncardiovasculardiseases
AT zhangyanjing effectsofferroptosisoncardiovasculardiseases
AT zhoujinhan effectsofferroptosisoncardiovasculardiseases
AT zhangshuxia effectsofferroptosisoncardiovasculardiseases
AT wusisi effectsofferroptosisoncardiovasculardiseases