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Effects of Ferroptosis on Cardiovascular Diseases
Ferroptosis is a novel form of programmed cell death characterized by the accumulation of iron-dependent lipid peroxides, which causes membrane injury. Under the catalysis of iron ions, cells deficient in glutathione peroxidase (GPX4) cannot preserve the balance in lipid oxidative metabolism, and th...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10175025/ https://www.ncbi.nlm.nih.gov/pubmed/37181809 http://dx.doi.org/10.1155/2023/6653202 |
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author | Xu, Jiayi Pi, Jinkui Zhang, Yanjing Zhou, Jinhan Zhang, Shuxia Wu, Sisi |
author_facet | Xu, Jiayi Pi, Jinkui Zhang, Yanjing Zhou, Jinhan Zhang, Shuxia Wu, Sisi |
author_sort | Xu, Jiayi |
collection | PubMed |
description | Ferroptosis is a novel form of programmed cell death characterized by the accumulation of iron-dependent lipid peroxides, which causes membrane injury. Under the catalysis of iron ions, cells deficient in glutathione peroxidase (GPX4) cannot preserve the balance in lipid oxidative metabolism, and the buildup of reactive oxygen species on the membrane lipids leads to cell death. An increasing body of evidence suggests that ferroptosis plays a significant role in the development and occurrence of cardiovascular diseases. In this paper, we mainly elaborated on the molecular mechanisms regulating ferroptosis and its impact on cardiovascular disease to lay the groundwork for future studies on the prophylaxis and treatment of this patient population. |
format | Online Article Text |
id | pubmed-10175025 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-101750252023-05-12 Effects of Ferroptosis on Cardiovascular Diseases Xu, Jiayi Pi, Jinkui Zhang, Yanjing Zhou, Jinhan Zhang, Shuxia Wu, Sisi Mediators Inflamm Review Article Ferroptosis is a novel form of programmed cell death characterized by the accumulation of iron-dependent lipid peroxides, which causes membrane injury. Under the catalysis of iron ions, cells deficient in glutathione peroxidase (GPX4) cannot preserve the balance in lipid oxidative metabolism, and the buildup of reactive oxygen species on the membrane lipids leads to cell death. An increasing body of evidence suggests that ferroptosis plays a significant role in the development and occurrence of cardiovascular diseases. In this paper, we mainly elaborated on the molecular mechanisms regulating ferroptosis and its impact on cardiovascular disease to lay the groundwork for future studies on the prophylaxis and treatment of this patient population. Hindawi 2023-05-04 /pmc/articles/PMC10175025/ /pubmed/37181809 http://dx.doi.org/10.1155/2023/6653202 Text en Copyright © 2023 Jiayi Xu et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Xu, Jiayi Pi, Jinkui Zhang, Yanjing Zhou, Jinhan Zhang, Shuxia Wu, Sisi Effects of Ferroptosis on Cardiovascular Diseases |
title | Effects of Ferroptosis on Cardiovascular Diseases |
title_full | Effects of Ferroptosis on Cardiovascular Diseases |
title_fullStr | Effects of Ferroptosis on Cardiovascular Diseases |
title_full_unstemmed | Effects of Ferroptosis on Cardiovascular Diseases |
title_short | Effects of Ferroptosis on Cardiovascular Diseases |
title_sort | effects of ferroptosis on cardiovascular diseases |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10175025/ https://www.ncbi.nlm.nih.gov/pubmed/37181809 http://dx.doi.org/10.1155/2023/6653202 |
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