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Influencing factors of efficacy and long‐term use of amrubicin in patients with small cell lung cancer

BACKGROUND: Amrubicin (AMR) has become the standard of care for post‐relapse small cell lung cancer (SCLC). It has also been reported to achieve long‐term disease control in patients with good treatment response. However, the optimal patient population for whom AMR is effective and the factors assoc...

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Autores principales: Takahara, Yutaka, Tanaka, Takuya, Ishige, Yoko, Shionoya, Ikuyo, Yamamura, Kouichi, Sakuma, Takashi, Nishiki, Kazuaki, Nakase, Keisuke, Nojiri, Masafumi, Kato, Ryo, Shinomiya, Shohei, Oikawa, Taku, Mizuno, Shiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons Australia, Ltd 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10175028/
https://www.ncbi.nlm.nih.gov/pubmed/36994539
http://dx.doi.org/10.1111/1759-7714.14871
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author Takahara, Yutaka
Tanaka, Takuya
Ishige, Yoko
Shionoya, Ikuyo
Yamamura, Kouichi
Sakuma, Takashi
Nishiki, Kazuaki
Nakase, Keisuke
Nojiri, Masafumi
Kato, Ryo
Shinomiya, Shohei
Oikawa, Taku
Mizuno, Shiro
author_facet Takahara, Yutaka
Tanaka, Takuya
Ishige, Yoko
Shionoya, Ikuyo
Yamamura, Kouichi
Sakuma, Takashi
Nishiki, Kazuaki
Nakase, Keisuke
Nojiri, Masafumi
Kato, Ryo
Shinomiya, Shohei
Oikawa, Taku
Mizuno, Shiro
author_sort Takahara, Yutaka
collection PubMed
description BACKGROUND: Amrubicin (AMR) has become the standard of care for post‐relapse small cell lung cancer (SCLC). It has also been reported to achieve long‐term disease control in patients with good treatment response. However, the optimal patient population for whom AMR is effective and the factors associated with long‐term disease control are yet to be identified. The aim of the study was to identify the clinical characteristics and factors associated with long‐term disease control in patients with recurrent SCLC who would benefit from AMR therapy. METHODS: The clinical records of 33 patients diagnosed with recurrent SCLC and treated with AMR were retrospectively reviewed. Clinical information was compared between patients who achieved disease control (effective group) and who developed disease progression (noneffective group) on the first efficacy assessment after AMR and between patients who continued AMR for more than seven cycles (maintenance group) and those who terminated treatment after 1–6 cycles (discontinuation group). RESULTS: The noneffective group included significantly more patients with AMR dose reductions after the second cycle (p = 0.006). AMR dose reduction was an independent risk factor for disease progression. The maintenance group had significantly lower pretreatment lactate dehydrogenase (LDH) levels than the discontinuation group (p = 0.046). A high LDH level was an independent risk factor for short AMR discontinuation. Overall survival was significantly longer in the effective group than in the noneffective group (p < 0.001). CONCLUSIONS: In AMR therapy for patients with relapsed SCLC, continuation of AMR without dose reduction after the second cycle may contribute to disease control and prolonged survival.
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spelling pubmed-101750282023-05-12 Influencing factors of efficacy and long‐term use of amrubicin in patients with small cell lung cancer Takahara, Yutaka Tanaka, Takuya Ishige, Yoko Shionoya, Ikuyo Yamamura, Kouichi Sakuma, Takashi Nishiki, Kazuaki Nakase, Keisuke Nojiri, Masafumi Kato, Ryo Shinomiya, Shohei Oikawa, Taku Mizuno, Shiro Thorac Cancer Original Articles BACKGROUND: Amrubicin (AMR) has become the standard of care for post‐relapse small cell lung cancer (SCLC). It has also been reported to achieve long‐term disease control in patients with good treatment response. However, the optimal patient population for whom AMR is effective and the factors associated with long‐term disease control are yet to be identified. The aim of the study was to identify the clinical characteristics and factors associated with long‐term disease control in patients with recurrent SCLC who would benefit from AMR therapy. METHODS: The clinical records of 33 patients diagnosed with recurrent SCLC and treated with AMR were retrospectively reviewed. Clinical information was compared between patients who achieved disease control (effective group) and who developed disease progression (noneffective group) on the first efficacy assessment after AMR and between patients who continued AMR for more than seven cycles (maintenance group) and those who terminated treatment after 1–6 cycles (discontinuation group). RESULTS: The noneffective group included significantly more patients with AMR dose reductions after the second cycle (p = 0.006). AMR dose reduction was an independent risk factor for disease progression. The maintenance group had significantly lower pretreatment lactate dehydrogenase (LDH) levels than the discontinuation group (p = 0.046). A high LDH level was an independent risk factor for short AMR discontinuation. Overall survival was significantly longer in the effective group than in the noneffective group (p < 0.001). CONCLUSIONS: In AMR therapy for patients with relapsed SCLC, continuation of AMR without dose reduction after the second cycle may contribute to disease control and prolonged survival. John Wiley & Sons Australia, Ltd 2023-03-30 /pmc/articles/PMC10175028/ /pubmed/36994539 http://dx.doi.org/10.1111/1759-7714.14871 Text en © 2023 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Articles
Takahara, Yutaka
Tanaka, Takuya
Ishige, Yoko
Shionoya, Ikuyo
Yamamura, Kouichi
Sakuma, Takashi
Nishiki, Kazuaki
Nakase, Keisuke
Nojiri, Masafumi
Kato, Ryo
Shinomiya, Shohei
Oikawa, Taku
Mizuno, Shiro
Influencing factors of efficacy and long‐term use of amrubicin in patients with small cell lung cancer
title Influencing factors of efficacy and long‐term use of amrubicin in patients with small cell lung cancer
title_full Influencing factors of efficacy and long‐term use of amrubicin in patients with small cell lung cancer
title_fullStr Influencing factors of efficacy and long‐term use of amrubicin in patients with small cell lung cancer
title_full_unstemmed Influencing factors of efficacy and long‐term use of amrubicin in patients with small cell lung cancer
title_short Influencing factors of efficacy and long‐term use of amrubicin in patients with small cell lung cancer
title_sort influencing factors of efficacy and long‐term use of amrubicin in patients with small cell lung cancer
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10175028/
https://www.ncbi.nlm.nih.gov/pubmed/36994539
http://dx.doi.org/10.1111/1759-7714.14871
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