Cargando…
Thymic atypical carcinoid tumors with elevated mitotic counts in a patient with multiple endocrine neoplasia: A case report
Thymic neuroendocrine tumors associated with multiple endocrine neoplasia are only defined as carcinoid and are not associated with large‐cell neuroendocrine carcinoma (LCNEC). We report the case of a multiple endocrine neoplasia type 1 patient with atypical carcinoid tumors with elevated mitotic co...
Autores principales: | , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons Australia, Ltd
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10175031/ https://www.ncbi.nlm.nih.gov/pubmed/36941083 http://dx.doi.org/10.1111/1759-7714.14863 |
_version_ | 1785040161533329408 |
---|---|
author | Hiro, Shuntaro Teranishi, Shuhei Sawazumi, Tomoe Nagaoka, Satoshi Sugimoto, Chihiro Nagayama, Hirokazu Segawa, Wataru Kajita, Yukihito Maeda, Chihiro Kubo, Sousuke Seki, Kenichi Tashiro, Ken Kobayashi, Nobuaki Yamamoto, Masaki Kudo, Makoto Kaneko, Takeshi |
author_facet | Hiro, Shuntaro Teranishi, Shuhei Sawazumi, Tomoe Nagaoka, Satoshi Sugimoto, Chihiro Nagayama, Hirokazu Segawa, Wataru Kajita, Yukihito Maeda, Chihiro Kubo, Sousuke Seki, Kenichi Tashiro, Ken Kobayashi, Nobuaki Yamamoto, Masaki Kudo, Makoto Kaneko, Takeshi |
author_sort | Hiro, Shuntaro |
collection | PubMed |
description | Thymic neuroendocrine tumors associated with multiple endocrine neoplasia are only defined as carcinoid and are not associated with large‐cell neuroendocrine carcinoma (LCNEC). We report the case of a multiple endocrine neoplasia type 1 patient with atypical carcinoid tumors with elevated mitotic counts (AC‐h), an intermediate condition between carcinoid and LCNEC. A 27‐year‐old man underwent surgery for an anterior mediastinal mass and was diagnosed with thymic LCNEC. Fifteen years later, a mass appeared at the same site, which was determined to be a postoperative recurrence based on the pathological results of a needle biopsy and the clinical course. The patient's disease remained stable for 10 months on anti‐programmed death‐ligand 1 antibody and platinum‐containing chemotherapy. The needle biopsy specimen was submitted for next‐generation sequencing, which revealed a MEN1 gene mutation, and after further examination, a diagnosis of multiple endocrine neoplasia type 1 was made. A re‐examination of the surgical specimen from 15 years prior showed that it corresponded to AC‐h. Although thymic AC‐h is classified as thymic LCNEC according to the current definition, our data suggests that a search for multiple endocrine neoplasia is warranted in such patients. |
format | Online Article Text |
id | pubmed-10175031 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley & Sons Australia, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-101750312023-05-12 Thymic atypical carcinoid tumors with elevated mitotic counts in a patient with multiple endocrine neoplasia: A case report Hiro, Shuntaro Teranishi, Shuhei Sawazumi, Tomoe Nagaoka, Satoshi Sugimoto, Chihiro Nagayama, Hirokazu Segawa, Wataru Kajita, Yukihito Maeda, Chihiro Kubo, Sousuke Seki, Kenichi Tashiro, Ken Kobayashi, Nobuaki Yamamoto, Masaki Kudo, Makoto Kaneko, Takeshi Thorac Cancer Case Reports Thymic neuroendocrine tumors associated with multiple endocrine neoplasia are only defined as carcinoid and are not associated with large‐cell neuroendocrine carcinoma (LCNEC). We report the case of a multiple endocrine neoplasia type 1 patient with atypical carcinoid tumors with elevated mitotic counts (AC‐h), an intermediate condition between carcinoid and LCNEC. A 27‐year‐old man underwent surgery for an anterior mediastinal mass and was diagnosed with thymic LCNEC. Fifteen years later, a mass appeared at the same site, which was determined to be a postoperative recurrence based on the pathological results of a needle biopsy and the clinical course. The patient's disease remained stable for 10 months on anti‐programmed death‐ligand 1 antibody and platinum‐containing chemotherapy. The needle biopsy specimen was submitted for next‐generation sequencing, which revealed a MEN1 gene mutation, and after further examination, a diagnosis of multiple endocrine neoplasia type 1 was made. A re‐examination of the surgical specimen from 15 years prior showed that it corresponded to AC‐h. Although thymic AC‐h is classified as thymic LCNEC according to the current definition, our data suggests that a search for multiple endocrine neoplasia is warranted in such patients. John Wiley & Sons Australia, Ltd 2023-03-20 /pmc/articles/PMC10175031/ /pubmed/36941083 http://dx.doi.org/10.1111/1759-7714.14863 Text en © 2023 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Reports Hiro, Shuntaro Teranishi, Shuhei Sawazumi, Tomoe Nagaoka, Satoshi Sugimoto, Chihiro Nagayama, Hirokazu Segawa, Wataru Kajita, Yukihito Maeda, Chihiro Kubo, Sousuke Seki, Kenichi Tashiro, Ken Kobayashi, Nobuaki Yamamoto, Masaki Kudo, Makoto Kaneko, Takeshi Thymic atypical carcinoid tumors with elevated mitotic counts in a patient with multiple endocrine neoplasia: A case report |
title | Thymic atypical carcinoid tumors with elevated mitotic counts in a patient with multiple endocrine neoplasia: A case report |
title_full | Thymic atypical carcinoid tumors with elevated mitotic counts in a patient with multiple endocrine neoplasia: A case report |
title_fullStr | Thymic atypical carcinoid tumors with elevated mitotic counts in a patient with multiple endocrine neoplasia: A case report |
title_full_unstemmed | Thymic atypical carcinoid tumors with elevated mitotic counts in a patient with multiple endocrine neoplasia: A case report |
title_short | Thymic atypical carcinoid tumors with elevated mitotic counts in a patient with multiple endocrine neoplasia: A case report |
title_sort | thymic atypical carcinoid tumors with elevated mitotic counts in a patient with multiple endocrine neoplasia: a case report |
topic | Case Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10175031/ https://www.ncbi.nlm.nih.gov/pubmed/36941083 http://dx.doi.org/10.1111/1759-7714.14863 |
work_keys_str_mv | AT hiroshuntaro thymicatypicalcarcinoidtumorswithelevatedmitoticcountsinapatientwithmultipleendocrineneoplasiaacasereport AT teranishishuhei thymicatypicalcarcinoidtumorswithelevatedmitoticcountsinapatientwithmultipleendocrineneoplasiaacasereport AT sawazumitomoe thymicatypicalcarcinoidtumorswithelevatedmitoticcountsinapatientwithmultipleendocrineneoplasiaacasereport AT nagaokasatoshi thymicatypicalcarcinoidtumorswithelevatedmitoticcountsinapatientwithmultipleendocrineneoplasiaacasereport AT sugimotochihiro thymicatypicalcarcinoidtumorswithelevatedmitoticcountsinapatientwithmultipleendocrineneoplasiaacasereport AT nagayamahirokazu thymicatypicalcarcinoidtumorswithelevatedmitoticcountsinapatientwithmultipleendocrineneoplasiaacasereport AT segawawataru thymicatypicalcarcinoidtumorswithelevatedmitoticcountsinapatientwithmultipleendocrineneoplasiaacasereport AT kajitayukihito thymicatypicalcarcinoidtumorswithelevatedmitoticcountsinapatientwithmultipleendocrineneoplasiaacasereport AT maedachihiro thymicatypicalcarcinoidtumorswithelevatedmitoticcountsinapatientwithmultipleendocrineneoplasiaacasereport AT kubosousuke thymicatypicalcarcinoidtumorswithelevatedmitoticcountsinapatientwithmultipleendocrineneoplasiaacasereport AT sekikenichi thymicatypicalcarcinoidtumorswithelevatedmitoticcountsinapatientwithmultipleendocrineneoplasiaacasereport AT tashiroken thymicatypicalcarcinoidtumorswithelevatedmitoticcountsinapatientwithmultipleendocrineneoplasiaacasereport AT kobayashinobuaki thymicatypicalcarcinoidtumorswithelevatedmitoticcountsinapatientwithmultipleendocrineneoplasiaacasereport AT yamamotomasaki thymicatypicalcarcinoidtumorswithelevatedmitoticcountsinapatientwithmultipleendocrineneoplasiaacasereport AT kudomakoto thymicatypicalcarcinoidtumorswithelevatedmitoticcountsinapatientwithmultipleendocrineneoplasiaacasereport AT kanekotakeshi thymicatypicalcarcinoidtumorswithelevatedmitoticcountsinapatientwithmultipleendocrineneoplasiaacasereport |