Integrative Genetic Manipulation of Plasmodium cynomolgi Reveals Multidrug Resistance-1 Y976F Associated With Increased In Vitro Susceptibility to Mefloquine

The lack of a long-term in vitro culture method has severely restricted the study of Plasmodium vivax, in part because it limits genetic manipulation and reverse genetics. We used the recently optimized Plasmodium cynomolgi Berok in vitro culture model to investigate the putative P. vivax drug resis...

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Detalles Bibliográficos
Autores principales: Ward, Kurt E, Christensen, Peter, Racklyeft, Annie, Dhingra, Satish K, Chua, Adeline C Y, Remmert, Caroline, Suwanarusk, Rossarin, Matheson, Jessica, Blackman, Michael J, Kaneko, Osamu, Kyle, Dennis E, Lee, Marcus C S, Moon, Robert W, Snounou, Georges, Rénia, Laurent, Fidock, David A, Russell, Bruce, Bifani, Pablo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Major Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10175063/
https://www.ncbi.nlm.nih.gov/pubmed/36478252
http://dx.doi.org/10.1093/infdis/jiac469

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