Prevalence of Parvovirus B19 Viremia Among German Blood Donations and the Relationship to ABO and Rhesus Blood Group Antigens

BACKGROUND: Asymptomatic blood donors can transmit human parvovirus B19 (B19V). METHODS: We assessed the B19V prevalence among a large cohort of blood donations collected in Germany during 2015–2018. RESULTS: In total, 167 123 donations were screened for B19V deoxyribonucleic acid with 22 cases of v...

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Detalles Bibliográficos
Autores principales: Healy, Katie, Aulin, Linda B S, Freij, Urban, Ellerstad, Marie, Brückle, Lena, Hillmering, Helen, Svae, Tor-Einar, Broliden, Kristina, Gustafsson, Rasmus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10175064/
https://www.ncbi.nlm.nih.gov/pubmed/36408632
http://dx.doi.org/10.1093/infdis/jiac456
Descripción
Sumario:BACKGROUND: Asymptomatic blood donors can transmit human parvovirus B19 (B19V). METHODS: We assessed the B19V prevalence among a large cohort of blood donations collected in Germany during 2015–2018. RESULTS: In total, 167 123 donations were screened for B19V deoxyribonucleic acid with 22 cases of viremia identified (0.013% positive). Infections peaked at a 4-year interval and the highest number of cases occurred in the summer months. All 22 infections were found in rhesus D-antigen-positive donations, suggesting a protective factor in donors who lack this antigen. CONCLUSIONS: These findings contribute to our understanding of risk factors for B19V infection among central European blood and plasma donors.

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