Prevalence of Parvovirus B19 Viremia Among German Blood Donations and the Relationship to ABO and Rhesus Blood Group Antigens

BACKGROUND: Asymptomatic blood donors can transmit human parvovirus B19 (B19V). METHODS: We assessed the B19V prevalence among a large cohort of blood donations collected in Germany during 2015–2018. RESULTS: In total, 167 123 donations were screened for B19V deoxyribonucleic acid with 22 cases of v...

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Autores principales: Healy, Katie, Aulin, Linda B S, Freij, Urban, Ellerstad, Marie, Brückle, Lena, Hillmering, Helen, Svae, Tor-Einar, Broliden, Kristina, Gustafsson, Rasmus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10175064/
https://www.ncbi.nlm.nih.gov/pubmed/36408632
http://dx.doi.org/10.1093/infdis/jiac456
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author Healy, Katie
Aulin, Linda B S
Freij, Urban
Ellerstad, Marie
Brückle, Lena
Hillmering, Helen
Svae, Tor-Einar
Broliden, Kristina
Gustafsson, Rasmus
author_facet Healy, Katie
Aulin, Linda B S
Freij, Urban
Ellerstad, Marie
Brückle, Lena
Hillmering, Helen
Svae, Tor-Einar
Broliden, Kristina
Gustafsson, Rasmus
author_sort Healy, Katie
collection PubMed
description BACKGROUND: Asymptomatic blood donors can transmit human parvovirus B19 (B19V). METHODS: We assessed the B19V prevalence among a large cohort of blood donations collected in Germany during 2015–2018. RESULTS: In total, 167 123 donations were screened for B19V deoxyribonucleic acid with 22 cases of viremia identified (0.013% positive). Infections peaked at a 4-year interval and the highest number of cases occurred in the summer months. All 22 infections were found in rhesus D-antigen-positive donations, suggesting a protective factor in donors who lack this antigen. CONCLUSIONS: These findings contribute to our understanding of risk factors for B19V infection among central European blood and plasma donors.
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spelling pubmed-101750642023-05-13 Prevalence of Parvovirus B19 Viremia Among German Blood Donations and the Relationship to ABO and Rhesus Blood Group Antigens Healy, Katie Aulin, Linda B S Freij, Urban Ellerstad, Marie Brückle, Lena Hillmering, Helen Svae, Tor-Einar Broliden, Kristina Gustafsson, Rasmus J Infect Dis Brief Report BACKGROUND: Asymptomatic blood donors can transmit human parvovirus B19 (B19V). METHODS: We assessed the B19V prevalence among a large cohort of blood donations collected in Germany during 2015–2018. RESULTS: In total, 167 123 donations were screened for B19V deoxyribonucleic acid with 22 cases of viremia identified (0.013% positive). Infections peaked at a 4-year interval and the highest number of cases occurred in the summer months. All 22 infections were found in rhesus D-antigen-positive donations, suggesting a protective factor in donors who lack this antigen. CONCLUSIONS: These findings contribute to our understanding of risk factors for B19V infection among central European blood and plasma donors. Oxford University Press 2022-11-21 /pmc/articles/PMC10175064/ /pubmed/36408632 http://dx.doi.org/10.1093/infdis/jiac456 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
Healy, Katie
Aulin, Linda B S
Freij, Urban
Ellerstad, Marie
Brückle, Lena
Hillmering, Helen
Svae, Tor-Einar
Broliden, Kristina
Gustafsson, Rasmus
Prevalence of Parvovirus B19 Viremia Among German Blood Donations and the Relationship to ABO and Rhesus Blood Group Antigens
title Prevalence of Parvovirus B19 Viremia Among German Blood Donations and the Relationship to ABO and Rhesus Blood Group Antigens
title_full Prevalence of Parvovirus B19 Viremia Among German Blood Donations and the Relationship to ABO and Rhesus Blood Group Antigens
title_fullStr Prevalence of Parvovirus B19 Viremia Among German Blood Donations and the Relationship to ABO and Rhesus Blood Group Antigens
title_full_unstemmed Prevalence of Parvovirus B19 Viremia Among German Blood Donations and the Relationship to ABO and Rhesus Blood Group Antigens
title_short Prevalence of Parvovirus B19 Viremia Among German Blood Donations and the Relationship to ABO and Rhesus Blood Group Antigens
title_sort prevalence of parvovirus b19 viremia among german blood donations and the relationship to abo and rhesus blood group antigens
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10175064/
https://www.ncbi.nlm.nih.gov/pubmed/36408632
http://dx.doi.org/10.1093/infdis/jiac456
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