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The link between the sphingolipid rheostat and obstructive sleep apnea

Chronic inflammation induced by hypoxia during sleep is an important mechanism of microvascular damage in OSA patients. In this study, we investigated the role of the sphingosine rheostat, which has diverse inflammatory effects. Thirty-seven healthy subjects and 31 patients with OSA were recruited....

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Autores principales: Horváth, Péter, Büdi, Lilla, Hammer, Dániel, Varga, Rita, Losonczy, György, Tárnoki, Ádám Domonkos, Tárnoki, Dávid László, Mészáros, Martina, Bikov, András
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10175248/
https://www.ncbi.nlm.nih.gov/pubmed/37169814
http://dx.doi.org/10.1038/s41598-023-34717-4
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author Horváth, Péter
Büdi, Lilla
Hammer, Dániel
Varga, Rita
Losonczy, György
Tárnoki, Ádám Domonkos
Tárnoki, Dávid László
Mészáros, Martina
Bikov, András
author_facet Horváth, Péter
Büdi, Lilla
Hammer, Dániel
Varga, Rita
Losonczy, György
Tárnoki, Ádám Domonkos
Tárnoki, Dávid László
Mészáros, Martina
Bikov, András
author_sort Horváth, Péter
collection PubMed
description Chronic inflammation induced by hypoxia during sleep is an important mechanism of microvascular damage in OSA patients. In this study, we investigated the role of the sphingosine rheostat, which has diverse inflammatory effects. Thirty-seven healthy subjects and 31 patients with OSA were recruited. We collected data on demographics and comorbidities. Plasma sphingosine-1-phosphate and ceramide antibody concentrations were measured by ELISA. The results were compared between the OSA and control groups, and the correlations between these measurements and markers of disease severity and comorbidities were explored. Ceramide antibody levels were significantly elevated in OSA patients (892.17 ng/ml) vs. controls (209.55 ng/ml). S1P levels were also significantly higher in patients with OSA (1760.0 pg/ml) than in controls (290.35 pg/ml, p < 0.001). The ceramide antibody concentration showed correlations with BMI (ρ = 0.25, p = 0.04), CRP (ρ = 0.36, p = 0.005), AHI (ρ = 0.43, p < 0.001), ODI (ρ = 0.43, p < 0.001), TST90% (ρ = 0.35, p = 0.004) and the lowest oxygen saturation (ρ =  0.37, p = 0.001) in the whole study population but not when patients with OSA were analyzed separately. The elevated ceramide antibody and sphingosine-1-phosphate concentrations in patients suffering from OSA suggests their involvement in the pathomechanism of OSA and its comorbidities.
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spelling pubmed-101752482023-05-13 The link between the sphingolipid rheostat and obstructive sleep apnea Horváth, Péter Büdi, Lilla Hammer, Dániel Varga, Rita Losonczy, György Tárnoki, Ádám Domonkos Tárnoki, Dávid László Mészáros, Martina Bikov, András Sci Rep Article Chronic inflammation induced by hypoxia during sleep is an important mechanism of microvascular damage in OSA patients. In this study, we investigated the role of the sphingosine rheostat, which has diverse inflammatory effects. Thirty-seven healthy subjects and 31 patients with OSA were recruited. We collected data on demographics and comorbidities. Plasma sphingosine-1-phosphate and ceramide antibody concentrations were measured by ELISA. The results were compared between the OSA and control groups, and the correlations between these measurements and markers of disease severity and comorbidities were explored. Ceramide antibody levels were significantly elevated in OSA patients (892.17 ng/ml) vs. controls (209.55 ng/ml). S1P levels were also significantly higher in patients with OSA (1760.0 pg/ml) than in controls (290.35 pg/ml, p < 0.001). The ceramide antibody concentration showed correlations with BMI (ρ = 0.25, p = 0.04), CRP (ρ = 0.36, p = 0.005), AHI (ρ = 0.43, p < 0.001), ODI (ρ = 0.43, p < 0.001), TST90% (ρ = 0.35, p = 0.004) and the lowest oxygen saturation (ρ =  0.37, p = 0.001) in the whole study population but not when patients with OSA were analyzed separately. The elevated ceramide antibody and sphingosine-1-phosphate concentrations in patients suffering from OSA suggests their involvement in the pathomechanism of OSA and its comorbidities. Nature Publishing Group UK 2023-05-11 /pmc/articles/PMC10175248/ /pubmed/37169814 http://dx.doi.org/10.1038/s41598-023-34717-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Horváth, Péter
Büdi, Lilla
Hammer, Dániel
Varga, Rita
Losonczy, György
Tárnoki, Ádám Domonkos
Tárnoki, Dávid László
Mészáros, Martina
Bikov, András
The link between the sphingolipid rheostat and obstructive sleep apnea
title The link between the sphingolipid rheostat and obstructive sleep apnea
title_full The link between the sphingolipid rheostat and obstructive sleep apnea
title_fullStr The link between the sphingolipid rheostat and obstructive sleep apnea
title_full_unstemmed The link between the sphingolipid rheostat and obstructive sleep apnea
title_short The link between the sphingolipid rheostat and obstructive sleep apnea
title_sort link between the sphingolipid rheostat and obstructive sleep apnea
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10175248/
https://www.ncbi.nlm.nih.gov/pubmed/37169814
http://dx.doi.org/10.1038/s41598-023-34717-4
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