Multimodal perturbation analyses of cyclin-dependent kinases reveal a network of synthetic lethalities associated with cell-cycle regulation and transcriptional regulation

Cell-cycle control is accomplished by cyclin-dependent kinases (CDKs), motivating extensive research into CDK targeting small-molecule drugs as cancer therapeutics. Here we use combinatorial CRISPR/Cas9 perturbations to uncover an extensive network of functional interdependencies among CDKs and rela...

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Detalles Bibliográficos
Autores principales: Ford, Kyle, Munson, Brenton P., Fong, Samson H., Panwala, Rebecca, Chu, Wai Keung, Rainaldi, Joseph, Plongthongkum, Nongluk, Arunachalam, Vinayagam, Kostrowicki, Jarek, Meluzzi, Dario, Kreisberg, Jason F., Jensen-Pergakes, Kristen, VanArsdale, Todd, Paul, Thomas, Tamayo, Pablo, Zhang, Kun, Bienkowska, Jadwiga, Mali, Prashant, Ideker, Trey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10175263/
https://www.ncbi.nlm.nih.gov/pubmed/37169829
http://dx.doi.org/10.1038/s41598-023-33329-2

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