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Respiratory arousal threshold among patients with isolated sleep apnea and with comorbid insomnia (COMISA)

Insomnia and obstructive sleep apnea (OSA) are common sleep disorders and frequently coexist (COMISA). Arousals from sleep may be a common link explaining the frequent comorbidity of both disorders. Respiratory arousal threshold (AT) is a physiologic measurement of the level of respiratory effort to...

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Autores principales: Yanagimori, Marcela, Fernandes, Mariana D., Garcia, Michelle L., Scudeller, Paula G., Carvalho, Carlos R. R., Edwards, Bradley, Lorenzi-Filho, Geraldo, Genta, Pedro R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10175295/
https://www.ncbi.nlm.nih.gov/pubmed/37169833
http://dx.doi.org/10.1038/s41598-023-34002-4
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author Yanagimori, Marcela
Fernandes, Mariana D.
Garcia, Michelle L.
Scudeller, Paula G.
Carvalho, Carlos R. R.
Edwards, Bradley
Lorenzi-Filho, Geraldo
Genta, Pedro R.
author_facet Yanagimori, Marcela
Fernandes, Mariana D.
Garcia, Michelle L.
Scudeller, Paula G.
Carvalho, Carlos R. R.
Edwards, Bradley
Lorenzi-Filho, Geraldo
Genta, Pedro R.
author_sort Yanagimori, Marcela
collection PubMed
description Insomnia and obstructive sleep apnea (OSA) are common sleep disorders and frequently coexist (COMISA). Arousals from sleep may be a common link explaining the frequent comorbidity of both disorders. Respiratory arousal threshold (AT) is a physiologic measurement of the level of respiratory effort to trigger an arousal from sleep. The impact of COMISA on AT is not known. We hypothesized that a low AT is more common among COMISA than among patients with OSA without insomnia. Participants referred for OSA diagnosis underwent a type 3 sleep study and answered the insomnia severity index (ISI) questionnaire and the Epworth sleepiness scale. Participants with an ISI score ≥ 15 were defined as having insomnia. Sleep apnea was defined as an apnea hypopnea index (AHI) ≥ 15 events/h. Low AT was determined using a previously validated score based on 3 polysomnography variables (AHI, nadir SpO(2) and the frequency of hypopneas). OSA-only (n = 51) and COMISA (n = 52) participants had similar age (61[52–68] vs 60[53–65] years), body-mass index (31.3[27.7–36.2] vs 32.2[29.5–38.3] kg/m(2)) and OSA severity (40.2[27.5–60] vs 37.55[27.9–65.2] events/h): all p = NS. OSA-only group had significantly more males than the COMISA group (58% vs 33%, p = 0.013. The proportion of participants with a low AT among OSA-only and COMISA groups was similar (29 vs 33%, p = NS). The similar proportion of low AT among COMISA and patients with OSA suggests that the respiratory arousal threshold may not be related to the increased arousability of insomnia.
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spelling pubmed-101752952023-05-13 Respiratory arousal threshold among patients with isolated sleep apnea and with comorbid insomnia (COMISA) Yanagimori, Marcela Fernandes, Mariana D. Garcia, Michelle L. Scudeller, Paula G. Carvalho, Carlos R. R. Edwards, Bradley Lorenzi-Filho, Geraldo Genta, Pedro R. Sci Rep Article Insomnia and obstructive sleep apnea (OSA) are common sleep disorders and frequently coexist (COMISA). Arousals from sleep may be a common link explaining the frequent comorbidity of both disorders. Respiratory arousal threshold (AT) is a physiologic measurement of the level of respiratory effort to trigger an arousal from sleep. The impact of COMISA on AT is not known. We hypothesized that a low AT is more common among COMISA than among patients with OSA without insomnia. Participants referred for OSA diagnosis underwent a type 3 sleep study and answered the insomnia severity index (ISI) questionnaire and the Epworth sleepiness scale. Participants with an ISI score ≥ 15 were defined as having insomnia. Sleep apnea was defined as an apnea hypopnea index (AHI) ≥ 15 events/h. Low AT was determined using a previously validated score based on 3 polysomnography variables (AHI, nadir SpO(2) and the frequency of hypopneas). OSA-only (n = 51) and COMISA (n = 52) participants had similar age (61[52–68] vs 60[53–65] years), body-mass index (31.3[27.7–36.2] vs 32.2[29.5–38.3] kg/m(2)) and OSA severity (40.2[27.5–60] vs 37.55[27.9–65.2] events/h): all p = NS. OSA-only group had significantly more males than the COMISA group (58% vs 33%, p = 0.013. The proportion of participants with a low AT among OSA-only and COMISA groups was similar (29 vs 33%, p = NS). The similar proportion of low AT among COMISA and patients with OSA suggests that the respiratory arousal threshold may not be related to the increased arousability of insomnia. Nature Publishing Group UK 2023-05-11 /pmc/articles/PMC10175295/ /pubmed/37169833 http://dx.doi.org/10.1038/s41598-023-34002-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Yanagimori, Marcela
Fernandes, Mariana D.
Garcia, Michelle L.
Scudeller, Paula G.
Carvalho, Carlos R. R.
Edwards, Bradley
Lorenzi-Filho, Geraldo
Genta, Pedro R.
Respiratory arousal threshold among patients with isolated sleep apnea and with comorbid insomnia (COMISA)
title Respiratory arousal threshold among patients with isolated sleep apnea and with comorbid insomnia (COMISA)
title_full Respiratory arousal threshold among patients with isolated sleep apnea and with comorbid insomnia (COMISA)
title_fullStr Respiratory arousal threshold among patients with isolated sleep apnea and with comorbid insomnia (COMISA)
title_full_unstemmed Respiratory arousal threshold among patients with isolated sleep apnea and with comorbid insomnia (COMISA)
title_short Respiratory arousal threshold among patients with isolated sleep apnea and with comorbid insomnia (COMISA)
title_sort respiratory arousal threshold among patients with isolated sleep apnea and with comorbid insomnia (comisa)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10175295/
https://www.ncbi.nlm.nih.gov/pubmed/37169833
http://dx.doi.org/10.1038/s41598-023-34002-4
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