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Factors influencing successful reconstruction of tympanic membrane perforations: a systematic review and meta-analysis
PURPOSE: Based on a systematic review and meta-analysis, our study aimed to provide information about the factors that influence the success of tympanic membrane reconstruction. METHODS: Our systematic search was conducted on November 24, 2021, using the CENTRAL, Embase, and MEDLINE databases. Obser...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10175362/ https://www.ncbi.nlm.nih.gov/pubmed/36811654 http://dx.doi.org/10.1007/s00405-023-07831-2 |
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author | Illés, Kata Gergő, Dorottya Keresztély, Zsuzsanna Dembrovszky, Fanni Fehérvári, Péter Bánvölgyi, András Csupor, Dezső Hegyi, Péter Horváth, Tamás |
author_facet | Illés, Kata Gergő, Dorottya Keresztély, Zsuzsanna Dembrovszky, Fanni Fehérvári, Péter Bánvölgyi, András Csupor, Dezső Hegyi, Péter Horváth, Tamás |
author_sort | Illés, Kata |
collection | PubMed |
description | PURPOSE: Based on a systematic review and meta-analysis, our study aimed to provide information about the factors that influence the success of tympanic membrane reconstruction. METHODS: Our systematic search was conducted on November 24, 2021, using the CENTRAL, Embase, and MEDLINE databases. Observational studies with a minimum of 12 months of follow-up on type I tympanoplasty or myringoplasty were included, while non-English articles, patients with cholesteatoma or specific inflammatory diseases, and ossiculoplasty cases were excluded. The protocol was registered on PROSPERO (registration number: CRD42021289240) and PRISMA reporting guideline was used. Risk of bias was evaluated with the QUIPS tool. A random effect model was used in the analyses. Primary outcome was the rate of closed tympanic cavities. RESULTS: After duplicate removal, 9454 articles were found, of which 39 cohort studies were included. Results of four analyses showed significant effects: age (OR: 0.62, CI 0.50; 0.78, p value: 0.0002), size of the perforation (OR: 0.52, CI 0.29; 0.94, p value: 0.033), opposite ear condition (OR: 0.32, CI 0.12; 0.85, p value: 0.028), and the surgeon’s experience (OR: 0.42, CI 0.26; 0.67, p value: 0.005), while prior adenoid surgery, smoking, the site of the perforation, and discharge of the ear did not. Four factors: etiology, Eustachian tube function, concomitant allergic rhinitis, and duration of the ear discharge were analyzed qualitatively. CONCLUSIONS: The age of the patient, the size of the perforation, the opposite ear status, and the surgeon’s experience have a significant effect on the success of tympanic membrane reconstruction. Further comprehensive studies are needed to analyze the interactions between the factors. LEVEL OF EVIDENCE: Not applicable. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00405-023-07831-2. |
format | Online Article Text |
id | pubmed-10175362 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-101753622023-05-13 Factors influencing successful reconstruction of tympanic membrane perforations: a systematic review and meta-analysis Illés, Kata Gergő, Dorottya Keresztély, Zsuzsanna Dembrovszky, Fanni Fehérvári, Péter Bánvölgyi, András Csupor, Dezső Hegyi, Péter Horváth, Tamás Eur Arch Otorhinolaryngol Review Article PURPOSE: Based on a systematic review and meta-analysis, our study aimed to provide information about the factors that influence the success of tympanic membrane reconstruction. METHODS: Our systematic search was conducted on November 24, 2021, using the CENTRAL, Embase, and MEDLINE databases. Observational studies with a minimum of 12 months of follow-up on type I tympanoplasty or myringoplasty were included, while non-English articles, patients with cholesteatoma or specific inflammatory diseases, and ossiculoplasty cases were excluded. The protocol was registered on PROSPERO (registration number: CRD42021289240) and PRISMA reporting guideline was used. Risk of bias was evaluated with the QUIPS tool. A random effect model was used in the analyses. Primary outcome was the rate of closed tympanic cavities. RESULTS: After duplicate removal, 9454 articles were found, of which 39 cohort studies were included. Results of four analyses showed significant effects: age (OR: 0.62, CI 0.50; 0.78, p value: 0.0002), size of the perforation (OR: 0.52, CI 0.29; 0.94, p value: 0.033), opposite ear condition (OR: 0.32, CI 0.12; 0.85, p value: 0.028), and the surgeon’s experience (OR: 0.42, CI 0.26; 0.67, p value: 0.005), while prior adenoid surgery, smoking, the site of the perforation, and discharge of the ear did not. Four factors: etiology, Eustachian tube function, concomitant allergic rhinitis, and duration of the ear discharge were analyzed qualitatively. CONCLUSIONS: The age of the patient, the size of the perforation, the opposite ear status, and the surgeon’s experience have a significant effect on the success of tympanic membrane reconstruction. Further comprehensive studies are needed to analyze the interactions between the factors. LEVEL OF EVIDENCE: Not applicable. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00405-023-07831-2. Springer Berlin Heidelberg 2023-02-22 2023 /pmc/articles/PMC10175362/ /pubmed/36811654 http://dx.doi.org/10.1007/s00405-023-07831-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Article Illés, Kata Gergő, Dorottya Keresztély, Zsuzsanna Dembrovszky, Fanni Fehérvári, Péter Bánvölgyi, András Csupor, Dezső Hegyi, Péter Horváth, Tamás Factors influencing successful reconstruction of tympanic membrane perforations: a systematic review and meta-analysis |
title | Factors influencing successful reconstruction of tympanic membrane perforations: a systematic review and meta-analysis |
title_full | Factors influencing successful reconstruction of tympanic membrane perforations: a systematic review and meta-analysis |
title_fullStr | Factors influencing successful reconstruction of tympanic membrane perforations: a systematic review and meta-analysis |
title_full_unstemmed | Factors influencing successful reconstruction of tympanic membrane perforations: a systematic review and meta-analysis |
title_short | Factors influencing successful reconstruction of tympanic membrane perforations: a systematic review and meta-analysis |
title_sort | factors influencing successful reconstruction of tympanic membrane perforations: a systematic review and meta-analysis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10175362/ https://www.ncbi.nlm.nih.gov/pubmed/36811654 http://dx.doi.org/10.1007/s00405-023-07831-2 |
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