TREM2 gene expression associations with Alzheimer’s disease neuropathology are region-specific: implications for cortical versus subcortical microglia

Previous post-mortem assessments of TREM2 expression and its association with brain pathologies have been limited by sample size. This study sought to correlate region-specific TREM2 mRNA expression with diverse neuropathological measures at autopsy using a large sample size (N = 945) of bulk RNA se...

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Detalles Bibliográficos
Autores principales: Winfree, Rebecca L., Seto, Mabel, Dumitrescu, Logan, Menon, Vilas, De Jager, Philip, Wang, Yanling, Schneider, Julie, Bennett, David A., Jefferson, Angela L., Hohman, Timothy J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10175463/
https://www.ncbi.nlm.nih.gov/pubmed/36966244
http://dx.doi.org/10.1007/s00401-023-02564-2

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