UDP-glucuronate metabolism controls RIPK1-driven liver damage in nonalcoholic steatohepatitis

Hepatocyte apoptosis plays an essential role in the progression of nonalcoholic steatohepatitis (NASH). However, the molecular mechanisms underlying hepatocyte apoptosis remain unclear. Here, we identify UDP-glucose 6-dehydrogenase (UGDH) as a suppressor of NASH-associated liver damage by inhibiting...

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Detalles Bibliográficos
Autores principales: Zhang, Tao, Zhang, Na, Xing, Jing, Zhang, Shuhua, Chen, Yulu, Xu, Daichao, Gu, Jinyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10175487/
https://www.ncbi.nlm.nih.gov/pubmed/37169760
http://dx.doi.org/10.1038/s41467-023-38371-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10175487/
https://www.ncbi.nlm.nih.gov/pubmed/37169760
http://dx.doi.org/10.1038/s41467-023-38371-2

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