Cargando…
Exploring pharmaphylogeny from multiple perspectives: a case study on Lithospermeae
Lithospermeae Dumort., a tribe under the subfamily Boraginoidae, is a perennial herb containing approximately 470 species under 26 genera, primarily distributed in temperate and tropical regions. To gain a deeper understanding of the medicinal plants of Lithospermeae and better protect and develop p...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10175555/ https://www.ncbi.nlm.nih.gov/pubmed/37169837 http://dx.doi.org/10.1038/s41598-023-34830-4 |
_version_ | 1785040233554771968 |
---|---|
author | Yan, Yumei Wei, Xinxin Qiu, Bin Wang, Guoping Zhou, Baochang Zhang, Mingxu Liu, Yibo Li, Siqi Gao, Bowen Li, Minhui |
author_facet | Yan, Yumei Wei, Xinxin Qiu, Bin Wang, Guoping Zhou, Baochang Zhang, Mingxu Liu, Yibo Li, Siqi Gao, Bowen Li, Minhui |
author_sort | Yan, Yumei |
collection | PubMed |
description | Lithospermeae Dumort., a tribe under the subfamily Boraginoidae, is a perennial herb containing approximately 470 species under 26 genera, primarily distributed in temperate and tropical regions. To gain a deeper understanding of the medicinal plants of Lithospermeae and better protect and develop plant medicinal resources, the phytochemistry, pharmacology, and traditional use of Lithospermeae with medicinal value were analyzed. Phylogenetic analysis was carried out based on the internal transcribed spacer sequence. Through spatial analysis and the species distribution model, the spatial distribution pattern of Lithospermeae medicinal plants was analyzed. Meanwhile, the relevant targets and pathways involved in the pharmacological effects of commonly used medicinal plants were predicted using network pharmacology to further explore the genetic origin of Lithospermeae and enrich the pharmaphylogeny of medicinal plants. In this study, the chemical composition, traditional efficacy, and modern pharmacological activity of Lithospermeae were collected for the first time and analyzed in combination with the geographical distribution model, molecular phylogeny, and network pharmacology. Based on our findings, the pharmaphylogeny of Lithospermeae was preliminarily discussed, providing the scientific basis for basic research regarding Lithospermeae. Concurrently, this study explored the relationship between the development of the regional medicinal plant industry and the protection of biodiversity. Furthermore, our findings provide direction and theoretical guidance for the study of the phylogenetic relationships in medicinal plants and the development of Lithospermeae medicinal plant resources. |
format | Online Article Text |
id | pubmed-10175555 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-101755552023-05-13 Exploring pharmaphylogeny from multiple perspectives: a case study on Lithospermeae Yan, Yumei Wei, Xinxin Qiu, Bin Wang, Guoping Zhou, Baochang Zhang, Mingxu Liu, Yibo Li, Siqi Gao, Bowen Li, Minhui Sci Rep Article Lithospermeae Dumort., a tribe under the subfamily Boraginoidae, is a perennial herb containing approximately 470 species under 26 genera, primarily distributed in temperate and tropical regions. To gain a deeper understanding of the medicinal plants of Lithospermeae and better protect and develop plant medicinal resources, the phytochemistry, pharmacology, and traditional use of Lithospermeae with medicinal value were analyzed. Phylogenetic analysis was carried out based on the internal transcribed spacer sequence. Through spatial analysis and the species distribution model, the spatial distribution pattern of Lithospermeae medicinal plants was analyzed. Meanwhile, the relevant targets and pathways involved in the pharmacological effects of commonly used medicinal plants were predicted using network pharmacology to further explore the genetic origin of Lithospermeae and enrich the pharmaphylogeny of medicinal plants. In this study, the chemical composition, traditional efficacy, and modern pharmacological activity of Lithospermeae were collected for the first time and analyzed in combination with the geographical distribution model, molecular phylogeny, and network pharmacology. Based on our findings, the pharmaphylogeny of Lithospermeae was preliminarily discussed, providing the scientific basis for basic research regarding Lithospermeae. Concurrently, this study explored the relationship between the development of the regional medicinal plant industry and the protection of biodiversity. Furthermore, our findings provide direction and theoretical guidance for the study of the phylogenetic relationships in medicinal plants and the development of Lithospermeae medicinal plant resources. Nature Publishing Group UK 2023-05-11 /pmc/articles/PMC10175555/ /pubmed/37169837 http://dx.doi.org/10.1038/s41598-023-34830-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Yan, Yumei Wei, Xinxin Qiu, Bin Wang, Guoping Zhou, Baochang Zhang, Mingxu Liu, Yibo Li, Siqi Gao, Bowen Li, Minhui Exploring pharmaphylogeny from multiple perspectives: a case study on Lithospermeae |
title | Exploring pharmaphylogeny from multiple perspectives: a case study on Lithospermeae |
title_full | Exploring pharmaphylogeny from multiple perspectives: a case study on Lithospermeae |
title_fullStr | Exploring pharmaphylogeny from multiple perspectives: a case study on Lithospermeae |
title_full_unstemmed | Exploring pharmaphylogeny from multiple perspectives: a case study on Lithospermeae |
title_short | Exploring pharmaphylogeny from multiple perspectives: a case study on Lithospermeae |
title_sort | exploring pharmaphylogeny from multiple perspectives: a case study on lithospermeae |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10175555/ https://www.ncbi.nlm.nih.gov/pubmed/37169837 http://dx.doi.org/10.1038/s41598-023-34830-4 |
work_keys_str_mv | AT yanyumei exploringpharmaphylogenyfrommultipleperspectivesacasestudyonlithospermeae AT weixinxin exploringpharmaphylogenyfrommultipleperspectivesacasestudyonlithospermeae AT qiubin exploringpharmaphylogenyfrommultipleperspectivesacasestudyonlithospermeae AT wangguoping exploringpharmaphylogenyfrommultipleperspectivesacasestudyonlithospermeae AT zhoubaochang exploringpharmaphylogenyfrommultipleperspectivesacasestudyonlithospermeae AT zhangmingxu exploringpharmaphylogenyfrommultipleperspectivesacasestudyonlithospermeae AT liuyibo exploringpharmaphylogenyfrommultipleperspectivesacasestudyonlithospermeae AT lisiqi exploringpharmaphylogenyfrommultipleperspectivesacasestudyonlithospermeae AT gaobowen exploringpharmaphylogenyfrommultipleperspectivesacasestudyonlithospermeae AT liminhui exploringpharmaphylogenyfrommultipleperspectivesacasestudyonlithospermeae |