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The application of exosomes in the early diagnosis and treatment of osteoarthritis
With the increase in human lifespan and the aggravation of global aging, the incidence of osteoarthritis (OA) is increasing annually. To better manage and control the progression of OA, prompt diagnosis and treatment for early-stage OA are important. However, a sensitive diagnostic modality and ther...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10175594/ https://www.ncbi.nlm.nih.gov/pubmed/37188263 http://dx.doi.org/10.3389/fphar.2023.1154135 |
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author | Chen, Anjing Chen, Yangmengfan Rong, Xiao You, Xuanhe Wu, Diwei Zhou, Xinran Zeng, Weinan Zhou, Zongke |
author_facet | Chen, Anjing Chen, Yangmengfan Rong, Xiao You, Xuanhe Wu, Diwei Zhou, Xinran Zeng, Weinan Zhou, Zongke |
author_sort | Chen, Anjing |
collection | PubMed |
description | With the increase in human lifespan and the aggravation of global aging, the incidence of osteoarthritis (OA) is increasing annually. To better manage and control the progression of OA, prompt diagnosis and treatment for early-stage OA are important. However, a sensitive diagnostic modality and therapy for early OA have not been well developed. The exosome is a class of extracellular vesicles containing bioactive substances, that can be delivered directly from original cells to neighboring cells to modulate cellular activities through intercellular communication. In recent years, exosomes have been considered important in the early diagnosis and treatment of OA. Synovial fluid exosome and its encapsulated substances, e.g., microRNA, lncRNA, and proteins, can not only distinguish OA stages but also prevent the progression of OA by directly targeting cartilage or indirectly modulating the immune microenvironment in the joints. In this mini-review, we include recent studies on the diagnostic and therapeutic modalities of exosomes and hope to provide a new direction for the early diagnosis and treatment of OA disease in the future. |
format | Online Article Text |
id | pubmed-10175594 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-101755942023-05-13 The application of exosomes in the early diagnosis and treatment of osteoarthritis Chen, Anjing Chen, Yangmengfan Rong, Xiao You, Xuanhe Wu, Diwei Zhou, Xinran Zeng, Weinan Zhou, Zongke Front Pharmacol Pharmacology With the increase in human lifespan and the aggravation of global aging, the incidence of osteoarthritis (OA) is increasing annually. To better manage and control the progression of OA, prompt diagnosis and treatment for early-stage OA are important. However, a sensitive diagnostic modality and therapy for early OA have not been well developed. The exosome is a class of extracellular vesicles containing bioactive substances, that can be delivered directly from original cells to neighboring cells to modulate cellular activities through intercellular communication. In recent years, exosomes have been considered important in the early diagnosis and treatment of OA. Synovial fluid exosome and its encapsulated substances, e.g., microRNA, lncRNA, and proteins, can not only distinguish OA stages but also prevent the progression of OA by directly targeting cartilage or indirectly modulating the immune microenvironment in the joints. In this mini-review, we include recent studies on the diagnostic and therapeutic modalities of exosomes and hope to provide a new direction for the early diagnosis and treatment of OA disease in the future. Frontiers Media S.A. 2023-04-28 /pmc/articles/PMC10175594/ /pubmed/37188263 http://dx.doi.org/10.3389/fphar.2023.1154135 Text en Copyright © 2023 Chen, Chen, Rong, You, Wu, Zhou, Zeng and Zhou. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Chen, Anjing Chen, Yangmengfan Rong, Xiao You, Xuanhe Wu, Diwei Zhou, Xinran Zeng, Weinan Zhou, Zongke The application of exosomes in the early diagnosis and treatment of osteoarthritis |
title | The application of exosomes in the early diagnosis and treatment of osteoarthritis |
title_full | The application of exosomes in the early diagnosis and treatment of osteoarthritis |
title_fullStr | The application of exosomes in the early diagnosis and treatment of osteoarthritis |
title_full_unstemmed | The application of exosomes in the early diagnosis and treatment of osteoarthritis |
title_short | The application of exosomes in the early diagnosis and treatment of osteoarthritis |
title_sort | application of exosomes in the early diagnosis and treatment of osteoarthritis |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10175594/ https://www.ncbi.nlm.nih.gov/pubmed/37188263 http://dx.doi.org/10.3389/fphar.2023.1154135 |
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