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The application of exosomes in the early diagnosis and treatment of osteoarthritis

With the increase in human lifespan and the aggravation of global aging, the incidence of osteoarthritis (OA) is increasing annually. To better manage and control the progression of OA, prompt diagnosis and treatment for early-stage OA are important. However, a sensitive diagnostic modality and ther...

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Autores principales: Chen, Anjing, Chen, Yangmengfan, Rong, Xiao, You, Xuanhe, Wu, Diwei, Zhou, Xinran, Zeng, Weinan, Zhou, Zongke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10175594/
https://www.ncbi.nlm.nih.gov/pubmed/37188263
http://dx.doi.org/10.3389/fphar.2023.1154135
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author Chen, Anjing
Chen, Yangmengfan
Rong, Xiao
You, Xuanhe
Wu, Diwei
Zhou, Xinran
Zeng, Weinan
Zhou, Zongke
author_facet Chen, Anjing
Chen, Yangmengfan
Rong, Xiao
You, Xuanhe
Wu, Diwei
Zhou, Xinran
Zeng, Weinan
Zhou, Zongke
author_sort Chen, Anjing
collection PubMed
description With the increase in human lifespan and the aggravation of global aging, the incidence of osteoarthritis (OA) is increasing annually. To better manage and control the progression of OA, prompt diagnosis and treatment for early-stage OA are important. However, a sensitive diagnostic modality and therapy for early OA have not been well developed. The exosome is a class of extracellular vesicles containing bioactive substances, that can be delivered directly from original cells to neighboring cells to modulate cellular activities through intercellular communication. In recent years, exosomes have been considered important in the early diagnosis and treatment of OA. Synovial fluid exosome and its encapsulated substances, e.g., microRNA, lncRNA, and proteins, can not only distinguish OA stages but also prevent the progression of OA by directly targeting cartilage or indirectly modulating the immune microenvironment in the joints. In this mini-review, we include recent studies on the diagnostic and therapeutic modalities of exosomes and hope to provide a new direction for the early diagnosis and treatment of OA disease in the future.
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spelling pubmed-101755942023-05-13 The application of exosomes in the early diagnosis and treatment of osteoarthritis Chen, Anjing Chen, Yangmengfan Rong, Xiao You, Xuanhe Wu, Diwei Zhou, Xinran Zeng, Weinan Zhou, Zongke Front Pharmacol Pharmacology With the increase in human lifespan and the aggravation of global aging, the incidence of osteoarthritis (OA) is increasing annually. To better manage and control the progression of OA, prompt diagnosis and treatment for early-stage OA are important. However, a sensitive diagnostic modality and therapy for early OA have not been well developed. The exosome is a class of extracellular vesicles containing bioactive substances, that can be delivered directly from original cells to neighboring cells to modulate cellular activities through intercellular communication. In recent years, exosomes have been considered important in the early diagnosis and treatment of OA. Synovial fluid exosome and its encapsulated substances, e.g., microRNA, lncRNA, and proteins, can not only distinguish OA stages but also prevent the progression of OA by directly targeting cartilage or indirectly modulating the immune microenvironment in the joints. In this mini-review, we include recent studies on the diagnostic and therapeutic modalities of exosomes and hope to provide a new direction for the early diagnosis and treatment of OA disease in the future. Frontiers Media S.A. 2023-04-28 /pmc/articles/PMC10175594/ /pubmed/37188263 http://dx.doi.org/10.3389/fphar.2023.1154135 Text en Copyright © 2023 Chen, Chen, Rong, You, Wu, Zhou, Zeng and Zhou. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Chen, Anjing
Chen, Yangmengfan
Rong, Xiao
You, Xuanhe
Wu, Diwei
Zhou, Xinran
Zeng, Weinan
Zhou, Zongke
The application of exosomes in the early diagnosis and treatment of osteoarthritis
title The application of exosomes in the early diagnosis and treatment of osteoarthritis
title_full The application of exosomes in the early diagnosis and treatment of osteoarthritis
title_fullStr The application of exosomes in the early diagnosis and treatment of osteoarthritis
title_full_unstemmed The application of exosomes in the early diagnosis and treatment of osteoarthritis
title_short The application of exosomes in the early diagnosis and treatment of osteoarthritis
title_sort application of exosomes in the early diagnosis and treatment of osteoarthritis
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10175594/
https://www.ncbi.nlm.nih.gov/pubmed/37188263
http://dx.doi.org/10.3389/fphar.2023.1154135
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