Forkhead box O3 attenuates osteoarthritis by suppressing ferroptosis through inactivation of NF-κB/MAPK signaling

BACKGROUND: Ferroptosis is a nonapoptotic cell death process that is characterized by lipid peroxidation and intracellular iron accumulation. As osteoarthritis (OA) progresses, inflammation or iron overload induces ferroptosis of chondrocytes. However, the genes that play a vital role in this proces...

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Detalles Bibliográficos
Autores principales: Zhao, Chen, Sun, Guantong, Li, Yaxin, Kong, Keyu, Li, Xiaodong, Kan, Tianyou, Yang, Fei, Wang, Lei, Wang, Xiaoqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chinese Speaking Orthopaedic Society 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10175709/
https://www.ncbi.nlm.nih.gov/pubmed/37188001
http://dx.doi.org/10.1016/j.jot.2023.02.005

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