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CRISPR editing demonstrates rs10490924 raised oxidative stress in iPSC-derived retinal cells from patients with ARMS2/HTRA1-related AMD

Genome-wide association studies (GWAS) have identified genetic risk loci for age-related macular degeneration (AMD) on the chromosome 10q26 (Chr10) locus and are tightly linked: the A69S (G>T) rs10490924 single-nucleotide variant (SNV) and the AATAA-rich insertion–deletion (indel, del443/ins54),...

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Detalles Bibliográficos
Autores principales:	Chang, Ya-Ju, Jenny, Laura A., Li, Yong-Shi, Cui, Xuan, Kong, Yang, Li, Yao, Sparrow, Janet R., Tsang, Stephen H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2023
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10175836/ https://www.ncbi.nlm.nih.gov/pubmed/37126685 http://dx.doi.org/10.1073/pnas.2215005120

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