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A human FLII gene variant alters sarcomeric actin thin filament length and predisposes to cardiomyopathy
To better understand the genetic basis of heart disease, we identified a variant in the Flightless-I homolog (FLII) gene that generates a R1243H missense change and predisposes to cardiac remodeling across multiple previous human genome-wide association studies (GWAS). Since this gene is of unknown...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10175844/ https://www.ncbi.nlm.nih.gov/pubmed/37126682 http://dx.doi.org/10.1073/pnas.2213696120 |