Transient and tunable CRISPRa regulation of APOBEC/AID genes for targeting hepatitis B virus

APOBEC/AID cytidine deaminases play an important role in innate immunity and antiviral defenses and were shown to suppress hepatitis B virus (HBV) replication by deaminating and destroying the major form of HBV genome, covalently closed circular DNA (cccDNA), without toxicity to the infected cells....

Descripción completa

Detalles Bibliográficos
Autores principales: Kostyushev, Dmitry, Brezgin, Sergey, Kostyusheva, Anastasiya, Ponomareva, Natalia, Bayurova, Ekaterina, Zakirova, Natalia, Kondrashova, Alla, Goptar, Irina, Nikiforova, Anastasiya, Sudina, Anna, Babin, Yurii, Gordeychuk, Ilya, Lukashev, Alexander, Zamyatnin, Andrey A., Ivanov, Alexander, Chulanov, Vladimir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10176074/
https://www.ncbi.nlm.nih.gov/pubmed/37187708
http://dx.doi.org/10.1016/j.omtn.2023.04.016

Ejemplares similares

Ejemplares similares