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Enhanced sensitivity of neutralizing antibody detection for different AAV serotypes using HeLa cells with overexpressed AAVR

A cell-based transduction inhibition assay (TI) is widely used in clinical trials to detect neutralizing antibody (NAb) titers against recombinant adeno-associated virus (rAAV), one of the most important criteria to exclude patients in gene therapy. Different cell lines are used in cell-based TI bec...

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Detalles Bibliográficos
Autores principales:	Zheng, Zhaoyue, Ye, Jingya, Leng, Mi, Gan, Chunmei, Tang, Na, Li, Wei, Valencia, C. Alexander, Dong, Biao, Chow, Hoi Yee
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10176094/ https://www.ncbi.nlm.nih.gov/pubmed/37188274 http://dx.doi.org/10.3389/fphar.2023.1188290

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