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A real-life analysis of patients with rheumatologic diseases on biological treatments: Data from TURKBIO Registry
Objective: TURKBIO registry, established in 2011, is the first nationwide biological database in Turkey. This study aimed to provide an overview of TURKBIO data collected by June 2018. Methods: The registry included adult patients with rheumatoid arthritis (RA), ankylosing spondylitis (AS), nonradio...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medical Research and Education Association
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10176217/ https://www.ncbi.nlm.nih.gov/pubmed/35546332 http://dx.doi.org/10.5152/eurjrheum.2022.21060 |
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author | Önen, Fatoş Can, Gerçek Çapar, Sedat Dalkılıç, Ediz Pehlivan, Yavuz Şenel, Soner Akar, Servet Koca, Süleyman Serdar Tufan, Abdurrahman Yazıcı, Ayten Yılmaz, Sema İnanç, Nevsun Sarı, İsmail Birlik, Merih Solmaz, Dilek Cefle, Ayşe Öztürk, Mehmet Akif Yolbaş, Servet Krogh, Niels Steen Yılmaz, Neslihan Erten, Şükran Bes, Cemal Gündüz, Özgül Soysal Göker, Berna Haznedaroğlu, Seminur Yavuz, Şule Çetin, Gözde Yildirim Yıldız, Fatih Direskeneli, Haner Akkoç, Nurullah |
author_facet | Önen, Fatoş Can, Gerçek Çapar, Sedat Dalkılıç, Ediz Pehlivan, Yavuz Şenel, Soner Akar, Servet Koca, Süleyman Serdar Tufan, Abdurrahman Yazıcı, Ayten Yılmaz, Sema İnanç, Nevsun Sarı, İsmail Birlik, Merih Solmaz, Dilek Cefle, Ayşe Öztürk, Mehmet Akif Yolbaş, Servet Krogh, Niels Steen Yılmaz, Neslihan Erten, Şükran Bes, Cemal Gündüz, Özgül Soysal Göker, Berna Haznedaroğlu, Seminur Yavuz, Şule Çetin, Gözde Yildirim Yıldız, Fatih Direskeneli, Haner Akkoç, Nurullah |
author_sort | Önen, Fatoş |
collection | PubMed |
description | Objective: TURKBIO registry, established in 2011, is the first nationwide biological database in Turkey. This study aimed to provide an overview of TURKBIO data collected by June 2018. Methods: The registry included adult patients with rheumatoid arthritis (RA), ankylosing spondylitis (AS), nonradiographic axial spondyloarthritis (nr-AxSpA), and psoriatic arthritis (PsA). Demographic and clinical features, disease activity markers, and other follow-up parameters, current and previous treatments, and adverse events were registered electronically at each visit using open-source software. The registration of patient-reported outcome measures was carried out electronically by the patients using touch screens. Results: TURKBIO registry included a total of 41,145 treatment series with biologicals. There were 2,588 patients with axSpA (2,459 AS and 129 nr-axSpA), 2,036 with RA, and 428 with PsA. The total number of patients, including those with other diagnoses, was 5,718. In the follow-up period, the number of patients and also visits steadily increased by years. The yearly mean number of visits per patient was found to be 2.3. Significant improvements in disease activity and health assessment parameters were observed following the biological treatments. Biologics were often given in combination with a conventional synthetic disease-modifying antirheumatic drug in patients with RA. Infections were the most commonly seen adverse events, followed by allergic reactions. Tuberculosis was observed in 12 patients, malignancy in 18, and treatment-related mortality in 31. Conclusion: TURKBIO provided a valuable real-life experience with the use of biologics in rheumatic diseases in Turkey. |
format | Online Article Text |
id | pubmed-10176217 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Medical Research and Education Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-101762172023-05-12 A real-life analysis of patients with rheumatologic diseases on biological treatments: Data from TURKBIO Registry Önen, Fatoş Can, Gerçek Çapar, Sedat Dalkılıç, Ediz Pehlivan, Yavuz Şenel, Soner Akar, Servet Koca, Süleyman Serdar Tufan, Abdurrahman Yazıcı, Ayten Yılmaz, Sema İnanç, Nevsun Sarı, İsmail Birlik, Merih Solmaz, Dilek Cefle, Ayşe Öztürk, Mehmet Akif Yolbaş, Servet Krogh, Niels Steen Yılmaz, Neslihan Erten, Şükran Bes, Cemal Gündüz, Özgül Soysal Göker, Berna Haznedaroğlu, Seminur Yavuz, Şule Çetin, Gözde Yildirim Yıldız, Fatih Direskeneli, Haner Akkoç, Nurullah Eur J Rheumatol Original Article Objective: TURKBIO registry, established in 2011, is the first nationwide biological database in Turkey. This study aimed to provide an overview of TURKBIO data collected by June 2018. Methods: The registry included adult patients with rheumatoid arthritis (RA), ankylosing spondylitis (AS), nonradiographic axial spondyloarthritis (nr-AxSpA), and psoriatic arthritis (PsA). Demographic and clinical features, disease activity markers, and other follow-up parameters, current and previous treatments, and adverse events were registered electronically at each visit using open-source software. The registration of patient-reported outcome measures was carried out electronically by the patients using touch screens. Results: TURKBIO registry included a total of 41,145 treatment series with biologicals. There were 2,588 patients with axSpA (2,459 AS and 129 nr-axSpA), 2,036 with RA, and 428 with PsA. The total number of patients, including those with other diagnoses, was 5,718. In the follow-up period, the number of patients and also visits steadily increased by years. The yearly mean number of visits per patient was found to be 2.3. Significant improvements in disease activity and health assessment parameters were observed following the biological treatments. Biologics were often given in combination with a conventional synthetic disease-modifying antirheumatic drug in patients with RA. Infections were the most commonly seen adverse events, followed by allergic reactions. Tuberculosis was observed in 12 patients, malignancy in 18, and treatment-related mortality in 31. Conclusion: TURKBIO provided a valuable real-life experience with the use of biologics in rheumatic diseases in Turkey. Medical Research and Education Association 2022-03-14 /pmc/articles/PMC10176217/ /pubmed/35546332 http://dx.doi.org/10.5152/eurjrheum.2022.21060 Text en Copyright©Author(s) - Available online at www.eurjrheumatol.org. https://creativecommons.org/licenses/by-nc/4.0/Content of this journal is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
spellingShingle | Original Article Önen, Fatoş Can, Gerçek Çapar, Sedat Dalkılıç, Ediz Pehlivan, Yavuz Şenel, Soner Akar, Servet Koca, Süleyman Serdar Tufan, Abdurrahman Yazıcı, Ayten Yılmaz, Sema İnanç, Nevsun Sarı, İsmail Birlik, Merih Solmaz, Dilek Cefle, Ayşe Öztürk, Mehmet Akif Yolbaş, Servet Krogh, Niels Steen Yılmaz, Neslihan Erten, Şükran Bes, Cemal Gündüz, Özgül Soysal Göker, Berna Haznedaroğlu, Seminur Yavuz, Şule Çetin, Gözde Yildirim Yıldız, Fatih Direskeneli, Haner Akkoç, Nurullah A real-life analysis of patients with rheumatologic diseases on biological treatments: Data from TURKBIO Registry |
title | A real-life analysis of patients with rheumatologic diseases on biological treatments: Data from TURKBIO Registry |
title_full | A real-life analysis of patients with rheumatologic diseases on biological treatments: Data from TURKBIO Registry |
title_fullStr | A real-life analysis of patients with rheumatologic diseases on biological treatments: Data from TURKBIO Registry |
title_full_unstemmed | A real-life analysis of patients with rheumatologic diseases on biological treatments: Data from TURKBIO Registry |
title_short | A real-life analysis of patients with rheumatologic diseases on biological treatments: Data from TURKBIO Registry |
title_sort | real-life analysis of patients with rheumatologic diseases on biological treatments: data from turkbio registry |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10176217/ https://www.ncbi.nlm.nih.gov/pubmed/35546332 http://dx.doi.org/10.5152/eurjrheum.2022.21060 |
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