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Updating the biologically based dose-response model for the nasal carcinogenicity of inhaled formaldehyde in the F344 rat

Chronic inhalation of formaldehyde by F344 rats causes nasal squamous cell carcinoma (SCC). This outcome is well-characterized: including dose-response and time course data for SCC, mechanistic endpoints, and nasal dosimetry. Conolly et al. (Toxicol. Sci. 75, 432–447, 2003) used these resources to d...

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Detalles Bibliográficos
Autores principales:	Conolly, Rory B, Schroeter, Jeffry, Kimbell, Julia S, Clewell, Harvey, Andersen, Melvin E, Gentry, P Robinan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Biotransformation, Toxicokinetics, and Pharmacokinetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10176246/ https://www.ncbi.nlm.nih.gov/pubmed/36912747 http://dx.doi.org/10.1093/toxsci/kfad028

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