Cholesterol synthesis enzyme SC4MOL is fine-tuned by sterols and targeted for degradation by the E3 ligase MARCHF6

Cholesterol biosynthesis is a highly regulated pathway, with over 20 enzymes controlled at the transcriptional and posttranslational levels. While some enzymes remain stable, increased sterol levels can trigger degradation of several synthesis enzymes via the ubiquitin-proteasome system. Of note, we...

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Detalles Bibliográficos
Autores principales: Qian, Lydia, Scott, Nicola A., Capell-Hattam, Isabelle M., Draper, Eliza A., Fenton, Nicole M., Luu, Winnie, Sharpe, Laura J., Brown, Andrew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article Collection: Cholesterol Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10176258/
https://www.ncbi.nlm.nih.gov/pubmed/36958722
http://dx.doi.org/10.1016/j.jlr.2023.100362

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