Allogeneic gene-edited HIV-specific CAR-T cells secreting PD-1 blocking scFv enhance specific cytotoxic activity against HIV Env(+) cells invivo

HIV-specific chimeric antigen receptor (CAR) T-cells have been developed to target HIV-1 infected CD4(+) T-cells that express HIV Env proteins. However, T cell exhaustion and the patient-specific autologous paradigm of CAR-T cell hurdled clinical applications. Here, we created HIV-specific CAR-T cel...

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Detalles Bibliográficos
Autores principales: Pan, Hanyu, Yang, Xinyi, Wang, Jing, Liang, Huitong, Jiang, Zhengtao, Zhao, Lin, Wang, Yanan, Liang, Zhiming, Shen, Xiaoting, Lin, Qinru, Liang, Yue, Yang, Jinglong, Lu, Panpan, Zhu, Yuqi, Li, Min, Wang, Pengfei, Xu, Jianqing, Lu, Hongzhou, Zhu, Huanzhang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wuhan Institute of Virology, Chinese Academy of Sciences 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10176442/
https://www.ncbi.nlm.nih.gov/pubmed/36657565
http://dx.doi.org/10.1016/j.virs.2023.01.003

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