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Use of left atrial appendage as an autologous tissue source for epicardial micrograft transplantation during LVAD implantation

We report here the first clinical use of the left atrial appendage (LAA) for epicardial micrograft transplantation during left ventricular assist device (LVAD) implantation. Previously, a sample from the right atrial appendage (RAA) has been available for processing and administering micrograft ther...

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Autores principales: Schmitto, Jan D., Kuuva, Aleksi, Kronström, Kai, Hanke, Jasmin S., Kankuri, Esko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10176448/
https://www.ncbi.nlm.nih.gov/pubmed/37187792
http://dx.doi.org/10.3389/fcvm.2023.1143886
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author Schmitto, Jan D.
Kuuva, Aleksi
Kronström, Kai
Hanke, Jasmin S.
Kankuri, Esko
author_facet Schmitto, Jan D.
Kuuva, Aleksi
Kronström, Kai
Hanke, Jasmin S.
Kankuri, Esko
author_sort Schmitto, Jan D.
collection PubMed
description We report here the first clinical use of the left atrial appendage (LAA) for epicardial micrograft transplantation during left ventricular assist device (LVAD) implantation. Previously, a sample from the right atrial appendage (RAA) has been available for processing and administering micrograft therapy in cardiac surgery. Both LAA and RAA are rich sources of various types of myocardial cells and are capable of providing both paracrine and cellular support to the failing myocardium. The surgical approach of LAA micrografting facilitates epicardial micrograft therapy dose escalation and treatment of larger myocardial areas than done previously. Moreover, as collection of treated vs. untreated tissues from the recipient heart is possible following LVAD implantation at the time of heart transplantation, the evaluation of the therapy's mechanism of action can be further deciphered at cellular and molecular levels. This LAA modification of the epicardial micrografting technique has the overall potential to facilitate the adoption of cardiac cell therapy during heart surgery.
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spelling pubmed-101764482023-05-13 Use of left atrial appendage as an autologous tissue source for epicardial micrograft transplantation during LVAD implantation Schmitto, Jan D. Kuuva, Aleksi Kronström, Kai Hanke, Jasmin S. Kankuri, Esko Front Cardiovasc Med Cardiovascular Medicine We report here the first clinical use of the left atrial appendage (LAA) for epicardial micrograft transplantation during left ventricular assist device (LVAD) implantation. Previously, a sample from the right atrial appendage (RAA) has been available for processing and administering micrograft therapy in cardiac surgery. Both LAA and RAA are rich sources of various types of myocardial cells and are capable of providing both paracrine and cellular support to the failing myocardium. The surgical approach of LAA micrografting facilitates epicardial micrograft therapy dose escalation and treatment of larger myocardial areas than done previously. Moreover, as collection of treated vs. untreated tissues from the recipient heart is possible following LVAD implantation at the time of heart transplantation, the evaluation of the therapy's mechanism of action can be further deciphered at cellular and molecular levels. This LAA modification of the epicardial micrografting technique has the overall potential to facilitate the adoption of cardiac cell therapy during heart surgery. Frontiers Media S.A. 2023-04-28 /pmc/articles/PMC10176448/ /pubmed/37187792 http://dx.doi.org/10.3389/fcvm.2023.1143886 Text en © 2023 Schmitto, Kuuva, Kronström, Hanke and Kankuri. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Schmitto, Jan D.
Kuuva, Aleksi
Kronström, Kai
Hanke, Jasmin S.
Kankuri, Esko
Use of left atrial appendage as an autologous tissue source for epicardial micrograft transplantation during LVAD implantation
title Use of left atrial appendage as an autologous tissue source for epicardial micrograft transplantation during LVAD implantation
title_full Use of left atrial appendage as an autologous tissue source for epicardial micrograft transplantation during LVAD implantation
title_fullStr Use of left atrial appendage as an autologous tissue source for epicardial micrograft transplantation during LVAD implantation
title_full_unstemmed Use of left atrial appendage as an autologous tissue source for epicardial micrograft transplantation during LVAD implantation
title_short Use of left atrial appendage as an autologous tissue source for epicardial micrograft transplantation during LVAD implantation
title_sort use of left atrial appendage as an autologous tissue source for epicardial micrograft transplantation during lvad implantation
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10176448/
https://www.ncbi.nlm.nih.gov/pubmed/37187792
http://dx.doi.org/10.3389/fcvm.2023.1143886
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