PYK-SubstitutionOME: an integrated database containing allosteric coupling, ligand affinity and mutational, structural, pathological, bioinformatic and computational information about pyruvate kinase isozymes

Interpreting changes in patient genomes, understanding how viruses evolve and engineering novel protein function all depend on accurately predicting the functional outcomes that arise from amino acid substitutions. To that end, the development of first-generation prediction algorithms was guided by...

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Detalles Bibliográficos
Autores principales: Swint-Kruse, Liskin, Dougherty, Larissa L, Page, Braelyn, Wu, Tiffany, O’Neil, Pierce T, Prasannan, Charulata B, Timmons, Cody, Tang, Qingling, Parente, Daniel J, Sreenivasan, Shwetha, Holyoak, Todd, Fenton, Aron W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10176505/
https://www.ncbi.nlm.nih.gov/pubmed/37171062
http://dx.doi.org/10.1093/database/baad030

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