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The Role of Nephrologists in the Management of Methanol Poisoning

Acute methanol poisoning is a rare but serious condition that can lead to significant morbidity and mortality. Toxic metabolites produced by methanol, primarily formaldehyde, can cause high anion gap metabolic acidosis, with the severity of clinical presentation ranging from mild symptoms to multi-o...

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Autores principales: Allata, Yassine, Chouhani, Basmat Amal, El bardai, Ghita, Kabbali, Nadia, Sqalli Houssaini, Tarik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10176525/
https://www.ncbi.nlm.nih.gov/pubmed/37187623
http://dx.doi.org/10.7759/cureus.37471
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author Allata, Yassine
Chouhani, Basmat Amal
El bardai, Ghita
Kabbali, Nadia
Sqalli Houssaini, Tarik
author_facet Allata, Yassine
Chouhani, Basmat Amal
El bardai, Ghita
Kabbali, Nadia
Sqalli Houssaini, Tarik
author_sort Allata, Yassine
collection PubMed
description Acute methanol poisoning is a rare but serious condition that can lead to significant morbidity and mortality. Toxic metabolites produced by methanol, primarily formaldehyde, can cause high anion gap metabolic acidosis, with the severity of clinical presentation ranging from mild symptoms to multi-organ failure. Nine people died and four patients needed treatment at our university hospital following a collective intoxication caused by the consumption of homemade alcoholic beverages in the central region of Morocco. The four patients presented to the emergency department with varying clinical symptoms, such as decreased visual acuity, severe agitation, and dyspnea. The laboratory tests confirmed high anion gap metabolic acidosis and a subsequent toxicology screen revealed that they had consumed methanol-tainted alcohol. The treatment regimen involved inhibiting the formation of toxic metabolites using an antidote (ethanol or fomepizole), correcting metabolic acidosis, enhancing the elimination of toxic metabolites through prolonged hemodialysis, and administering adjunctive therapies. While two patients had favorable outcomes, the other two died from multi-organ failure. These findings highlight the importance of prompt diagnosis and treatment in cases of methanol poisoning.
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spelling pubmed-101765252023-05-13 The Role of Nephrologists in the Management of Methanol Poisoning Allata, Yassine Chouhani, Basmat Amal El bardai, Ghita Kabbali, Nadia Sqalli Houssaini, Tarik Cureus Emergency Medicine Acute methanol poisoning is a rare but serious condition that can lead to significant morbidity and mortality. Toxic metabolites produced by methanol, primarily formaldehyde, can cause high anion gap metabolic acidosis, with the severity of clinical presentation ranging from mild symptoms to multi-organ failure. Nine people died and four patients needed treatment at our university hospital following a collective intoxication caused by the consumption of homemade alcoholic beverages in the central region of Morocco. The four patients presented to the emergency department with varying clinical symptoms, such as decreased visual acuity, severe agitation, and dyspnea. The laboratory tests confirmed high anion gap metabolic acidosis and a subsequent toxicology screen revealed that they had consumed methanol-tainted alcohol. The treatment regimen involved inhibiting the formation of toxic metabolites using an antidote (ethanol or fomepizole), correcting metabolic acidosis, enhancing the elimination of toxic metabolites through prolonged hemodialysis, and administering adjunctive therapies. While two patients had favorable outcomes, the other two died from multi-organ failure. These findings highlight the importance of prompt diagnosis and treatment in cases of methanol poisoning. Cureus 2023-04-12 /pmc/articles/PMC10176525/ /pubmed/37187623 http://dx.doi.org/10.7759/cureus.37471 Text en Copyright © 2023, Allata et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Emergency Medicine
Allata, Yassine
Chouhani, Basmat Amal
El bardai, Ghita
Kabbali, Nadia
Sqalli Houssaini, Tarik
The Role of Nephrologists in the Management of Methanol Poisoning
title The Role of Nephrologists in the Management of Methanol Poisoning
title_full The Role of Nephrologists in the Management of Methanol Poisoning
title_fullStr The Role of Nephrologists in the Management of Methanol Poisoning
title_full_unstemmed The Role of Nephrologists in the Management of Methanol Poisoning
title_short The Role of Nephrologists in the Management of Methanol Poisoning
title_sort role of nephrologists in the management of methanol poisoning
topic Emergency Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10176525/
https://www.ncbi.nlm.nih.gov/pubmed/37187623
http://dx.doi.org/10.7759/cureus.37471
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