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NIR-II Imaging and Sandwiched Plasmonic Biosensor for Ultrasensitive Intraoperative Definition of Tumor-Invaded Lymph Nodes
[Image: see text] Radical lymphadenectomy remains the cornerstone of preventing tumor metastasis through the lymphatic system. Current surgical resection of lymph nodes (LNs) based on fluorescence-guided surgery (FGS) suffers from low sensitivity/selectivity with only qualitative information, hamper...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10176571/ https://www.ncbi.nlm.nih.gov/pubmed/37071592 http://dx.doi.org/10.1021/acs.nanolett.3c00829 |
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author | Wang, Yajun Nan, Jingjie Ma, Huilong Xu, Jiajun Guo, Feifei Wang, Yufeng Liang, Yongye Zhang, Junhu Zhu, Shoujun |
author_facet | Wang, Yajun Nan, Jingjie Ma, Huilong Xu, Jiajun Guo, Feifei Wang, Yufeng Liang, Yongye Zhang, Junhu Zhu, Shoujun |
author_sort | Wang, Yajun |
collection | PubMed |
description | [Image: see text] Radical lymphadenectomy remains the cornerstone of preventing tumor metastasis through the lymphatic system. Current surgical resection of lymph nodes (LNs) based on fluorescence-guided surgery (FGS) suffers from low sensitivity/selectivity with only qualitative information, hampering accurate intraoperative decision-making. Herein, we develop a modularized theranostic system including NIR-II FGS and a sandwiched plasmonic chip (SPC). Intraoperative NIR-II FGS and detection of tumor-positive lymph nodes were performed on the gastric tumor to determine the feasibility of the modularized theranostic system in defining LN metastasis. Under the NIR-II imaging window, the orthotopic tumor and sentinel lymph nodes (SLNs) were successfully excised without ambient light interference in the operating room. Importantly, the SPC biosensor achieved 100% sensitivity and 100% specificity for tumor markers and realized rapid and high-throughput intraoperative SLN detection. We propose the synergetic design of combining the NIR-II FGS and suitable biosensor will substantially improve the efficiency of cancer diagnosis and therapy follow-up. |
format | Online Article Text |
id | pubmed-10176571 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-101765712023-05-13 NIR-II Imaging and Sandwiched Plasmonic Biosensor for Ultrasensitive Intraoperative Definition of Tumor-Invaded Lymph Nodes Wang, Yajun Nan, Jingjie Ma, Huilong Xu, Jiajun Guo, Feifei Wang, Yufeng Liang, Yongye Zhang, Junhu Zhu, Shoujun Nano Lett [Image: see text] Radical lymphadenectomy remains the cornerstone of preventing tumor metastasis through the lymphatic system. Current surgical resection of lymph nodes (LNs) based on fluorescence-guided surgery (FGS) suffers from low sensitivity/selectivity with only qualitative information, hampering accurate intraoperative decision-making. Herein, we develop a modularized theranostic system including NIR-II FGS and a sandwiched plasmonic chip (SPC). Intraoperative NIR-II FGS and detection of tumor-positive lymph nodes were performed on the gastric tumor to determine the feasibility of the modularized theranostic system in defining LN metastasis. Under the NIR-II imaging window, the orthotopic tumor and sentinel lymph nodes (SLNs) were successfully excised without ambient light interference in the operating room. Importantly, the SPC biosensor achieved 100% sensitivity and 100% specificity for tumor markers and realized rapid and high-throughput intraoperative SLN detection. We propose the synergetic design of combining the NIR-II FGS and suitable biosensor will substantially improve the efficiency of cancer diagnosis and therapy follow-up. American Chemical Society 2023-04-18 /pmc/articles/PMC10176571/ /pubmed/37071592 http://dx.doi.org/10.1021/acs.nanolett.3c00829 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Wang, Yajun Nan, Jingjie Ma, Huilong Xu, Jiajun Guo, Feifei Wang, Yufeng Liang, Yongye Zhang, Junhu Zhu, Shoujun NIR-II Imaging and Sandwiched Plasmonic Biosensor for Ultrasensitive Intraoperative Definition of Tumor-Invaded Lymph Nodes |
title | NIR-II Imaging
and Sandwiched Plasmonic Biosensor
for Ultrasensitive Intraoperative Definition of Tumor-Invaded Lymph
Nodes |
title_full | NIR-II Imaging
and Sandwiched Plasmonic Biosensor
for Ultrasensitive Intraoperative Definition of Tumor-Invaded Lymph
Nodes |
title_fullStr | NIR-II Imaging
and Sandwiched Plasmonic Biosensor
for Ultrasensitive Intraoperative Definition of Tumor-Invaded Lymph
Nodes |
title_full_unstemmed | NIR-II Imaging
and Sandwiched Plasmonic Biosensor
for Ultrasensitive Intraoperative Definition of Tumor-Invaded Lymph
Nodes |
title_short | NIR-II Imaging
and Sandwiched Plasmonic Biosensor
for Ultrasensitive Intraoperative Definition of Tumor-Invaded Lymph
Nodes |
title_sort | nir-ii imaging
and sandwiched plasmonic biosensor
for ultrasensitive intraoperative definition of tumor-invaded lymph
nodes |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10176571/ https://www.ncbi.nlm.nih.gov/pubmed/37071592 http://dx.doi.org/10.1021/acs.nanolett.3c00829 |
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