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NIR-II Imaging and Sandwiched Plasmonic Biosensor for Ultrasensitive Intraoperative Definition of Tumor-Invaded Lymph Nodes

[Image: see text] Radical lymphadenectomy remains the cornerstone of preventing tumor metastasis through the lymphatic system. Current surgical resection of lymph nodes (LNs) based on fluorescence-guided surgery (FGS) suffers from low sensitivity/selectivity with only qualitative information, hamper...

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Autores principales: Wang, Yajun, Nan, Jingjie, Ma, Huilong, Xu, Jiajun, Guo, Feifei, Wang, Yufeng, Liang, Yongye, Zhang, Junhu, Zhu, Shoujun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10176571/
https://www.ncbi.nlm.nih.gov/pubmed/37071592
http://dx.doi.org/10.1021/acs.nanolett.3c00829
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author Wang, Yajun
Nan, Jingjie
Ma, Huilong
Xu, Jiajun
Guo, Feifei
Wang, Yufeng
Liang, Yongye
Zhang, Junhu
Zhu, Shoujun
author_facet Wang, Yajun
Nan, Jingjie
Ma, Huilong
Xu, Jiajun
Guo, Feifei
Wang, Yufeng
Liang, Yongye
Zhang, Junhu
Zhu, Shoujun
author_sort Wang, Yajun
collection PubMed
description [Image: see text] Radical lymphadenectomy remains the cornerstone of preventing tumor metastasis through the lymphatic system. Current surgical resection of lymph nodes (LNs) based on fluorescence-guided surgery (FGS) suffers from low sensitivity/selectivity with only qualitative information, hampering accurate intraoperative decision-making. Herein, we develop a modularized theranostic system including NIR-II FGS and a sandwiched plasmonic chip (SPC). Intraoperative NIR-II FGS and detection of tumor-positive lymph nodes were performed on the gastric tumor to determine the feasibility of the modularized theranostic system in defining LN metastasis. Under the NIR-II imaging window, the orthotopic tumor and sentinel lymph nodes (SLNs) were successfully excised without ambient light interference in the operating room. Importantly, the SPC biosensor achieved 100% sensitivity and 100% specificity for tumor markers and realized rapid and high-throughput intraoperative SLN detection. We propose the synergetic design of combining the NIR-II FGS and suitable biosensor will substantially improve the efficiency of cancer diagnosis and therapy follow-up.
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spelling pubmed-101765712023-05-13 NIR-II Imaging and Sandwiched Plasmonic Biosensor for Ultrasensitive Intraoperative Definition of Tumor-Invaded Lymph Nodes Wang, Yajun Nan, Jingjie Ma, Huilong Xu, Jiajun Guo, Feifei Wang, Yufeng Liang, Yongye Zhang, Junhu Zhu, Shoujun Nano Lett [Image: see text] Radical lymphadenectomy remains the cornerstone of preventing tumor metastasis through the lymphatic system. Current surgical resection of lymph nodes (LNs) based on fluorescence-guided surgery (FGS) suffers from low sensitivity/selectivity with only qualitative information, hampering accurate intraoperative decision-making. Herein, we develop a modularized theranostic system including NIR-II FGS and a sandwiched plasmonic chip (SPC). Intraoperative NIR-II FGS and detection of tumor-positive lymph nodes were performed on the gastric tumor to determine the feasibility of the modularized theranostic system in defining LN metastasis. Under the NIR-II imaging window, the orthotopic tumor and sentinel lymph nodes (SLNs) were successfully excised without ambient light interference in the operating room. Importantly, the SPC biosensor achieved 100% sensitivity and 100% specificity for tumor markers and realized rapid and high-throughput intraoperative SLN detection. We propose the synergetic design of combining the NIR-II FGS and suitable biosensor will substantially improve the efficiency of cancer diagnosis and therapy follow-up. American Chemical Society 2023-04-18 /pmc/articles/PMC10176571/ /pubmed/37071592 http://dx.doi.org/10.1021/acs.nanolett.3c00829 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Wang, Yajun
Nan, Jingjie
Ma, Huilong
Xu, Jiajun
Guo, Feifei
Wang, Yufeng
Liang, Yongye
Zhang, Junhu
Zhu, Shoujun
NIR-II Imaging and Sandwiched Plasmonic Biosensor for Ultrasensitive Intraoperative Definition of Tumor-Invaded Lymph Nodes
title NIR-II Imaging and Sandwiched Plasmonic Biosensor for Ultrasensitive Intraoperative Definition of Tumor-Invaded Lymph Nodes
title_full NIR-II Imaging and Sandwiched Plasmonic Biosensor for Ultrasensitive Intraoperative Definition of Tumor-Invaded Lymph Nodes
title_fullStr NIR-II Imaging and Sandwiched Plasmonic Biosensor for Ultrasensitive Intraoperative Definition of Tumor-Invaded Lymph Nodes
title_full_unstemmed NIR-II Imaging and Sandwiched Plasmonic Biosensor for Ultrasensitive Intraoperative Definition of Tumor-Invaded Lymph Nodes
title_short NIR-II Imaging and Sandwiched Plasmonic Biosensor for Ultrasensitive Intraoperative Definition of Tumor-Invaded Lymph Nodes
title_sort nir-ii imaging and sandwiched plasmonic biosensor for ultrasensitive intraoperative definition of tumor-invaded lymph nodes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10176571/
https://www.ncbi.nlm.nih.gov/pubmed/37071592
http://dx.doi.org/10.1021/acs.nanolett.3c00829
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