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Insight into muscle stem cell regeneration and mechanobiology
Stem cells possess the unique ability to differentiate into specialized cell types. These specialized cell types can be used for regenerative medicine purposes such as cell therapy. Myosatellite cells, also known as skeletal muscle stem cells (MuSCs), play important roles in the growth, repair, and...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10176686/ https://www.ncbi.nlm.nih.gov/pubmed/37173707 http://dx.doi.org/10.1186/s13287-023-03363-y |
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author | Pang, Kuin Tian Loo, Larry Sai Weng Chia, Sean Ong, Francesca Yi Teng Yu, Hanry Walsh, Ian |
author_facet | Pang, Kuin Tian Loo, Larry Sai Weng Chia, Sean Ong, Francesca Yi Teng Yu, Hanry Walsh, Ian |
author_sort | Pang, Kuin Tian |
collection | PubMed |
description | Stem cells possess the unique ability to differentiate into specialized cell types. These specialized cell types can be used for regenerative medicine purposes such as cell therapy. Myosatellite cells, also known as skeletal muscle stem cells (MuSCs), play important roles in the growth, repair, and regeneration of skeletal muscle tissues. However, despite its therapeutic potential, the successful differentiation, proliferation, and expansion processes of MuSCs remain a significant challenge due to a variety of factors. For example, the growth and differentiation of MuSCs can be greatly influenced by actively replicating the MuSCs microenvironment (known as the niche) using mechanical forces. However, the molecular role of mechanobiology in MuSC growth, proliferation, and differentiation for regenerative medicine is still poorly understood. In this present review, we comprehensively summarize, compare, and critically analyze how different mechanical cues shape stem cell growth, proliferation, differentiation, and their potential role in disease development (Fig. 1). The insights developed from the mechanobiology of stem cells will also contribute to how these applications can be used for regenerative purposes using MuSCs. |
format | Online Article Text |
id | pubmed-10176686 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-101766862023-05-13 Insight into muscle stem cell regeneration and mechanobiology Pang, Kuin Tian Loo, Larry Sai Weng Chia, Sean Ong, Francesca Yi Teng Yu, Hanry Walsh, Ian Stem Cell Res Ther Review Stem cells possess the unique ability to differentiate into specialized cell types. These specialized cell types can be used for regenerative medicine purposes such as cell therapy. Myosatellite cells, also known as skeletal muscle stem cells (MuSCs), play important roles in the growth, repair, and regeneration of skeletal muscle tissues. However, despite its therapeutic potential, the successful differentiation, proliferation, and expansion processes of MuSCs remain a significant challenge due to a variety of factors. For example, the growth and differentiation of MuSCs can be greatly influenced by actively replicating the MuSCs microenvironment (known as the niche) using mechanical forces. However, the molecular role of mechanobiology in MuSC growth, proliferation, and differentiation for regenerative medicine is still poorly understood. In this present review, we comprehensively summarize, compare, and critically analyze how different mechanical cues shape stem cell growth, proliferation, differentiation, and their potential role in disease development (Fig. 1). The insights developed from the mechanobiology of stem cells will also contribute to how these applications can be used for regenerative purposes using MuSCs. BioMed Central 2023-05-12 /pmc/articles/PMC10176686/ /pubmed/37173707 http://dx.doi.org/10.1186/s13287-023-03363-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Pang, Kuin Tian Loo, Larry Sai Weng Chia, Sean Ong, Francesca Yi Teng Yu, Hanry Walsh, Ian Insight into muscle stem cell regeneration and mechanobiology |
title | Insight into muscle stem cell regeneration and mechanobiology |
title_full | Insight into muscle stem cell regeneration and mechanobiology |
title_fullStr | Insight into muscle stem cell regeneration and mechanobiology |
title_full_unstemmed | Insight into muscle stem cell regeneration and mechanobiology |
title_short | Insight into muscle stem cell regeneration and mechanobiology |
title_sort | insight into muscle stem cell regeneration and mechanobiology |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10176686/ https://www.ncbi.nlm.nih.gov/pubmed/37173707 http://dx.doi.org/10.1186/s13287-023-03363-y |
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