CRISPR/Cas9-based genome-wide screening of the deubiquitinase subfamily identifies USP3 as a protein stabilizer of REST blocking neuronal differentiation and promotes neuroblastoma tumorigenesis

BACKGROUND: The repressor element-1 silencing transcription factor (REST), a master transcriptional repressor, is essential for maintenance, self-renewal, and differentiation in neuroblastoma. An elevated expression of REST is associated with impaired neuronal differentiation, which results in aggre...

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Detalles Bibliográficos
Autores principales: Karapurkar, Janardhan Keshav, Kim, Min-Seong, Colaco, Jencia Carminha, Suresh, Bharathi, Sarodaya, Neha, Kim, Dong-Ho, Park, Chang-Hwan, Hong, Seok-Ho, Kim, Kye-Seong, Ramakrishna, Suresh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10176696/
https://www.ncbi.nlm.nih.gov/pubmed/37170124
http://dx.doi.org/10.1186/s13046-023-02694-1

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