Immunohistochemical expression of the hepatocyte growth factor in chromophobe renal cell carcinoma

BACKGROUND: The prognostic value of Hepatocyte growth factor (HGF) in non-clear cell renal cell carcinoma (RCC) is still unclear. The aim of this study is to evaluate the prognostic impact of HGF expression in a large cohort of chromophobe RCC (chRCC). METHODS: Patients who underwent renal surgery d...

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Autores principales: Erlmeier, Maximilian, Mikuteit, Marie, Zschäbitz, Stefanie, Autenrieth, Michael, Weichert, Wilko, Hartmann, Arndt, Steffens, Sandra, Erlmeier, Franziska
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10176764/
https://www.ncbi.nlm.nih.gov/pubmed/37170275
http://dx.doi.org/10.1186/s12894-023-01263-0
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author Erlmeier, Maximilian
Mikuteit, Marie
Zschäbitz, Stefanie
Autenrieth, Michael
Weichert, Wilko
Hartmann, Arndt
Steffens, Sandra
Erlmeier, Franziska
author_facet Erlmeier, Maximilian
Mikuteit, Marie
Zschäbitz, Stefanie
Autenrieth, Michael
Weichert, Wilko
Hartmann, Arndt
Steffens, Sandra
Erlmeier, Franziska
author_sort Erlmeier, Maximilian
collection PubMed
description BACKGROUND: The prognostic value of Hepatocyte growth factor (HGF) in non-clear cell renal cell carcinoma (RCC) is still unclear. The aim of this study is to evaluate the prognostic impact of HGF expression in a large cohort of chromophobe RCC (chRCC). METHODS: Patients who underwent renal surgery due to chRCC were recruited. Clinical data was retrospectively evaluated. Tumor specimen were analyzed for HGF expression by immunohistochemistry. RESULTS: 81 chRCC patients were eligible for analysis, thereof 37 (45.7%) patients were positive for HGF. No significant associations were found for HGF expression and clinical attributes in patients with chRCC. Kaplan-Meier analysis revealed no differences in 5-year overall survival (OS) for patients with HGF(−) compared to HGF(+) tumors (95.0% versus 90.9%; p = 0.410). CONCLUSIONS: In chRCC HGF expression is not associated with parameters of aggressiveness or survival.
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spelling pubmed-101767642023-05-13 Immunohistochemical expression of the hepatocyte growth factor in chromophobe renal cell carcinoma Erlmeier, Maximilian Mikuteit, Marie Zschäbitz, Stefanie Autenrieth, Michael Weichert, Wilko Hartmann, Arndt Steffens, Sandra Erlmeier, Franziska BMC Urol Research BACKGROUND: The prognostic value of Hepatocyte growth factor (HGF) in non-clear cell renal cell carcinoma (RCC) is still unclear. The aim of this study is to evaluate the prognostic impact of HGF expression in a large cohort of chromophobe RCC (chRCC). METHODS: Patients who underwent renal surgery due to chRCC were recruited. Clinical data was retrospectively evaluated. Tumor specimen were analyzed for HGF expression by immunohistochemistry. RESULTS: 81 chRCC patients were eligible for analysis, thereof 37 (45.7%) patients were positive for HGF. No significant associations were found for HGF expression and clinical attributes in patients with chRCC. Kaplan-Meier analysis revealed no differences in 5-year overall survival (OS) for patients with HGF(−) compared to HGF(+) tumors (95.0% versus 90.9%; p = 0.410). CONCLUSIONS: In chRCC HGF expression is not associated with parameters of aggressiveness or survival. BioMed Central 2023-05-11 /pmc/articles/PMC10176764/ /pubmed/37170275 http://dx.doi.org/10.1186/s12894-023-01263-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Erlmeier, Maximilian
Mikuteit, Marie
Zschäbitz, Stefanie
Autenrieth, Michael
Weichert, Wilko
Hartmann, Arndt
Steffens, Sandra
Erlmeier, Franziska
Immunohistochemical expression of the hepatocyte growth factor in chromophobe renal cell carcinoma
title Immunohistochemical expression of the hepatocyte growth factor in chromophobe renal cell carcinoma
title_full Immunohistochemical expression of the hepatocyte growth factor in chromophobe renal cell carcinoma
title_fullStr Immunohistochemical expression of the hepatocyte growth factor in chromophobe renal cell carcinoma
title_full_unstemmed Immunohistochemical expression of the hepatocyte growth factor in chromophobe renal cell carcinoma
title_short Immunohistochemical expression of the hepatocyte growth factor in chromophobe renal cell carcinoma
title_sort immunohistochemical expression of the hepatocyte growth factor in chromophobe renal cell carcinoma
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10176764/
https://www.ncbi.nlm.nih.gov/pubmed/37170275
http://dx.doi.org/10.1186/s12894-023-01263-0
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