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Discovery of novel bicyclic[3.3.0]proline peptidyl α-ketoamides as potent 3CL-protease inhibitors for SARS-CoV-2

The outbreak of SARS-CoV-2 has caused global crisis on health and economics. The multiple drug-drug interaction risk associated with ritonavir warrants specialized assessment before using Paxlovid. Here we report a multiple-round SAR study to provide a novel bicyclic[3.3.0]proline peptidyl α-ketoami...

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Detalles Bibliográficos
Autores principales:	Chen, Xiaoxin, Li, Peng, Huang, Jianzhou, Yang, Yaxun, Zhang, Haoyu, Wang, Zheng, Zhu, Zhenzhen, Wang, Jingjing, Zhang, Jianchen, Chen, Kevin, He, Haiying, Long, Chaofeng, Chen, Shuhui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Published by Elsevier Ltd. 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10176891/ https://www.ncbi.nlm.nih.gov/pubmed/37182612 http://dx.doi.org/10.1016/j.bmcl.2023.129324

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