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Radioiodine-131 Therapy Used for Differentiated Thyroid Cancer Can Impair Titanium Dental Implants: An In Vitro Analysis
SIMPLE SUMMARY: The alterations on dental implants seen after therapeutic radioiodine-131 exposure have important clinical impact. Several microstructural alterations start to appear at 24 h up to 2 weeks after exposure; this affects the pores walls which tend to be eroded. ABSTRACT: Background: The...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10177135/ https://www.ncbi.nlm.nih.gov/pubmed/37174023 http://dx.doi.org/10.3390/cancers15092558 |
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author | Piciu, Doina Bran, Simion Moldovan, Marioara Varvara, Simona Piciu, Andra Cuc, Stanca Moisescu-Goia, Cristina Barbus, Elena Mester, Alexandru Onisor, Florin |
author_facet | Piciu, Doina Bran, Simion Moldovan, Marioara Varvara, Simona Piciu, Andra Cuc, Stanca Moisescu-Goia, Cristina Barbus, Elena Mester, Alexandru Onisor, Florin |
author_sort | Piciu, Doina |
collection | PubMed |
description | SIMPLE SUMMARY: The alterations on dental implants seen after therapeutic radioiodine-131 exposure have important clinical impact. Several microstructural alterations start to appear at 24 h up to 2 weeks after exposure; this affects the pores walls which tend to be eroded. ABSTRACT: Background: The aim was to assess, in vitro, the effects of radioiodine-131 (I-131) on the structure of titanium implants. Material and Methods: A total of 28 titanium implants were divided into 7 groups (n = 4) and irradiated at 0, 6, 12, 24, 48, 192 and 384 hours. At the end of the experiment, each sample was investigated via scanning electron microscopy (SEM) and electrochemical measures. Results: The control sample revealed a smooth and compact surface. The small micro-sized porosity is slightly visible at the macroscopic level, but the precise details cannot be observed. A mild exposure to the radioactive solution for 6 to 24 h showed a good preservation of the macro-structural aspects such as thread details and surface quality. Significant changes occurred after 48 h of exposure. It was noticed that the open-circuit potential (OCP) value of the non-irradiated implants move toward more noble potentials during the first 40 min of exposure to the artificial saliva and then stabilizes at a constant value of −143 mV. A displacement of the OCP values toward more negative values was observed for all irradiated implants; these potential shifts are decreasing, as the irradiation period of the tested implants increased. Conclusion: After exposure to I-131, the structure of titanium implants is well preserved up to 12 h. The eroded particles start to appear in the microstructural details after 24 h of exposure and their numbers progressively increase up to 384 h after exposure. |
format | Online Article Text |
id | pubmed-10177135 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101771352023-05-13 Radioiodine-131 Therapy Used for Differentiated Thyroid Cancer Can Impair Titanium Dental Implants: An In Vitro Analysis Piciu, Doina Bran, Simion Moldovan, Marioara Varvara, Simona Piciu, Andra Cuc, Stanca Moisescu-Goia, Cristina Barbus, Elena Mester, Alexandru Onisor, Florin Cancers (Basel) Article SIMPLE SUMMARY: The alterations on dental implants seen after therapeutic radioiodine-131 exposure have important clinical impact. Several microstructural alterations start to appear at 24 h up to 2 weeks after exposure; this affects the pores walls which tend to be eroded. ABSTRACT: Background: The aim was to assess, in vitro, the effects of radioiodine-131 (I-131) on the structure of titanium implants. Material and Methods: A total of 28 titanium implants were divided into 7 groups (n = 4) and irradiated at 0, 6, 12, 24, 48, 192 and 384 hours. At the end of the experiment, each sample was investigated via scanning electron microscopy (SEM) and electrochemical measures. Results: The control sample revealed a smooth and compact surface. The small micro-sized porosity is slightly visible at the macroscopic level, but the precise details cannot be observed. A mild exposure to the radioactive solution for 6 to 24 h showed a good preservation of the macro-structural aspects such as thread details and surface quality. Significant changes occurred after 48 h of exposure. It was noticed that the open-circuit potential (OCP) value of the non-irradiated implants move toward more noble potentials during the first 40 min of exposure to the artificial saliva and then stabilizes at a constant value of −143 mV. A displacement of the OCP values toward more negative values was observed for all irradiated implants; these potential shifts are decreasing, as the irradiation period of the tested implants increased. Conclusion: After exposure to I-131, the structure of titanium implants is well preserved up to 12 h. The eroded particles start to appear in the microstructural details after 24 h of exposure and their numbers progressively increase up to 384 h after exposure. MDPI 2023-04-29 /pmc/articles/PMC10177135/ /pubmed/37174023 http://dx.doi.org/10.3390/cancers15092558 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Piciu, Doina Bran, Simion Moldovan, Marioara Varvara, Simona Piciu, Andra Cuc, Stanca Moisescu-Goia, Cristina Barbus, Elena Mester, Alexandru Onisor, Florin Radioiodine-131 Therapy Used for Differentiated Thyroid Cancer Can Impair Titanium Dental Implants: An In Vitro Analysis |
title | Radioiodine-131 Therapy Used for Differentiated Thyroid Cancer Can Impair Titanium Dental Implants: An In Vitro Analysis |
title_full | Radioiodine-131 Therapy Used for Differentiated Thyroid Cancer Can Impair Titanium Dental Implants: An In Vitro Analysis |
title_fullStr | Radioiodine-131 Therapy Used for Differentiated Thyroid Cancer Can Impair Titanium Dental Implants: An In Vitro Analysis |
title_full_unstemmed | Radioiodine-131 Therapy Used for Differentiated Thyroid Cancer Can Impair Titanium Dental Implants: An In Vitro Analysis |
title_short | Radioiodine-131 Therapy Used for Differentiated Thyroid Cancer Can Impair Titanium Dental Implants: An In Vitro Analysis |
title_sort | radioiodine-131 therapy used for differentiated thyroid cancer can impair titanium dental implants: an in vitro analysis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10177135/ https://www.ncbi.nlm.nih.gov/pubmed/37174023 http://dx.doi.org/10.3390/cancers15092558 |
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