Cargando…

Targeting FGFRs Using PD173074 as a Novel Therapeutic Strategy in Cholangiocarcinoma

SIMPLE SUMMARY: Cholangiocarcinoma (CCA) is an architecturally complex and highly heterogeneous tumour and is difficult to diagnose at early stages due to its late onset and asymptomatic nature. Recent studies have focused on the Fibroblast Growth Factor Receptors (FGFRs), a sub-family of Tyrosine K...

Descripción completa

Detalles Bibliográficos
Autores principales:	Balasubramanian, Brinda, Yacqub-Usman, Kiren, Venkatraman, Simran, Myint, Kyaw Zwar, Juengsamarn, Jitlada, Sarkhampee, Poowanai, Lertsawatvicha, Nithi, Sripa, Jittiyawadee, Kuakpaetoon, Thiti, Suriyonplengsaeng, Chinnawut, Wongprasert, Kanokpan, Grabowska, Anna M., Bates, David O., Janvilisri, Tavan, Tohtong, Rutaiwan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10177182/ https://www.ncbi.nlm.nih.gov/pubmed/37173994 http://dx.doi.org/10.3390/cancers15092528

Ejemplares similares

Effect of Combining EGFR Tyrosine Kinase Inhibitors and Cytotoxic Agents on Cholangiocarcinoma Cells
por: Boonsri, Boonyakorn, et al.
Publicado: (2021)

Dysregulation of microRNA in cholangiocarcinoma identified through a meta-analysis of microRNA profiling
por: Likhitrattanapisal, Somsak, et al.
Publicado: (2020)

Co-Clinical Trials: An Innovative Drug Development Platform for Cholangiocarcinoma
por: Balasubramanian, Brinda, et al.
Publicado: (2021)

RTK25: A Comprehensive Molecular Profiling Strategy in Cholangiocarcinoma Using an Integrated Bioinformatics Approach
por: Balasubramanian, Brinda, et al.
Publicado: (2021)

Survival of Patients with Cholangiocarcinoma Receiving Surgical Treatment in an O. viverrini Endemic Area in Thailand: A Retrospective Cohort Study
por: Chansitthichok, Satsawat, et al.
Publicado: (2020)

In Silico Target Identification of Galangin, as an Herbal Flavonoid against Cholangiocarcinoma
por: Balasubramanian, Brinda, et al.
Publicado: (2022)

Novel Serum Biomarkers to Differentiate Cholangiocarcinoma from Benign Biliary Tract Diseases Using a Proteomic Approach
por: Janvilisri, Tavan, et al.
Publicado: (2015)

Downregulation of ABCA1 and ABCG1 transporters by simvastatin in cholangiocarcinoma cells
por: Seeree, Pattaya, et al.
Publicado: (2019)

Severe congenital nemaline myopathy with primary pulmonary lymphangiectasia: unusual clinical presentation and review of the literature
por: Waisayarat, Jariya, et al.
Publicado: (2015)

Lysosomal Sequestration Impairs the Activity of the Preclinical FGFR Inhibitor PD173074
por: Englinger, Bernhard, et al.
Publicado: (2018)

Gadd45β silencing impaired viability and metastatic phenotypes in cholangiocarcinoma cells by modulating the EMT pathway
por: Myint, Kyaw Zwar, et al.
Publicado: (2018)

Fibroblast Growth Factor Receptors (FGFRs): Structures and Small Molecule Inhibitors
por: Dai, Shuyan, et al.
Publicado: (2019)

Fibroblast Growth Factor Receptors (FGFRs) and Noncanonical Partners in Cancer Signaling
por: Ferguson, Harriet R., et al.
Publicado: (2021)

Omics-Based Identification of Biomarkers for Nasopharyngeal Carcinoma
por: Janvilisri, Tavan
Publicado: (2015)

CD24 induces the invasion of cholangiocarcinoma cells by upregulating CXCR4 and increasing the phosphorylation of ERK1/2
por: LEELAWAT, KAWIN, et al.
Publicado: (2013)

Role of mTOR inhibitor in cholangiocarcinoma cell progression
por: MOOLTHIYA, PENPAK, et al.
Publicado: (2014)

Functional roles of fibroblast growth factor receptors (FGFRs) signaling in human cancers
por: Tiong, Kai Hung, et al.
Publicado: (2013)

PD173074, a selective FGFR inhibitor, reverses MRP7 (ABCC10)-mediated MDR
por: Anreddy, Nagaraju, et al.
Publicado: (2014)

Immunohistochemistry of sarcolemmal membrane-associated proteins in formalin-fixed and paraffin-embedded skeletal muscle tissue: a promising tool for the diagnostic evaluation of common muscular dystrophies
por: Suriyonplengsaeng, Chinnawut, et al.
Publicado: (2017)

Inhibition of Metastatic Potential in Breast Carcinoma In Vivo and In Vitro through Targeting VEGFRs and FGFRs
por: Chien, Ming-Hsien, et al.
Publicado: (2013)

Role of Fibroblast Growth Factors Receptors (FGFRs) in Brain Tumors, Focus on Astrocytoma and Glioblastoma
por: Ardizzone, Alessio, et al.
Publicado: (2020)

The FGFR1 inhibitor PD173074 induces mesenchymal–epithelial transition through the transcription factor AP-1
por: Nguyen, P T, et al.
Publicado: (2013)

TNF-α-induced ICAM-1 expression and monocyte adhesion in human RPE cells is mediated in part through autocrine VEGF stimulation
por: Thichanpiang, Peeradech, et al.
Publicado: (2014)

Nasopharyngeal Carcinoma Signaling Pathway: An Update on Molecular Biomarkers
por: Tulalamba, Warut, et al.
Publicado: (2012)

Transcriptional Regulation of Cancer Immune Checkpoints: Emerging Strategies for Immunotherapy
por: Venkatraman, Simran, et al.
Publicado: (2020)

Molecularly Guided Drug Repurposing for Cholangiocarcinoma: An Integrative Bioinformatic Approach
por: Venkatraman, Simran, et al.
Publicado: (2022)

Fibroblast Growth Factor Receptors (FGFRs) in Human Sperm: Expression, Functionality and Involvement in Motility Regulation
por: Saucedo, Lucía, et al.
Publicado: (2015)

Key necroptotic proteins are required for Smac mimetic-mediated sensitization of cholangiocarcinoma cells to TNF-α and chemotherapeutic gemcitabine-induced necroptosis
por: Akara-amornthum, Perawatt, et al.
Publicado: (2020)

TC-1 Overexpression Promotes Cell Proliferation in Human Non-Small Cell Lung Cancer that Can Be Inhibited by PD173074
por: Lei, Jie, et al.
Publicado: (2014)

Differential Expression of FGFRs Signaling Pathway Components in Bladder Cancer: A Step Toward Personalized Medicine
por: Ousati Ashtiani, Z, et al.
Publicado: (2017)

FGFs/FGFRs-dependent signalling in regulation of steroid hormone receptors – implications for therapy of luminal breast cancer
por: Piasecka, Dominika, et al.
Publicado: (2019)

Lectin affinity chromatography and quantitative proteomic analysis reveal that galectin-3 is associated with metastasis in nasopharyngeal carcinoma
por: Aimjongjun, Sathid, et al.
Publicado: (2020)

Purification and Evaluation of N-benzyl Cinnamamide from Red Seaweed Gracilaria fisheri as an Inhibitor of Vibrio harveyi AI-2 Quorum Sensing
por: Karnjana, Kulwadee, et al.
Publicado: (2020)

Molecular Changes in Opisthorchis viverrini (Southeast Asian Liver Fluke) during the Transition from the Juvenile to the Adult Stage
por: Jex, Aaron R., et al.
Publicado: (2012)

Associations between microRNA binding site SNPs in FGFs and FGFRs and the risk of non-syndromic orofacial cleft
por: Li, Dandan, et al.
Publicado: (2016)

Advances in Molecular Diagnostics
por: Janvilisri, Tavan, et al.
Publicado: (2013)

Depolymerized Fractions of Sulfated Galactans Extracted from Gracilaria fisheri and Their Antibacterial Activity against Vibrio parahaemolyticus and Vibrio harveyi
por: Kamble, Manoj Tukaram, et al.
Publicado: (2022)

Characteristics and Impact of HPV-Associated p16 Expression on Head and Neck Squamous Cell Carcinoma in Thai Patients
por: Jiarpinitnun, Chuleeporn, et al.
Publicado: (2020)

NMR backbone assignments of the tyrosine kinase domain of human fibroblast growth factor receptor 3 in apo state and in complex with inhibitor PD173074
por: Sanfelice, Domenico, et al.
Publicado: (2018)

An Omics Perspective on Molecular Biomarkers for Diagnosis, Prognosis, and Therapeutics of Cholangiocarcinoma
por: Seeree, Pattaya, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_93m79vn7mjk1pp59nos5ml41qr